A new water-soluble ligand for efficient copper-catalyzed Huisgen cycloaddition of aliphatic azides and alkynes

被引：20
|
作者：
Szafranski, Przemyslaw W. [1 ]
Kasza, Patryk [1 ,2 ]
Cegla, Marek T. [1 ]
机构：
[1] Jagiellonian Univ, Fac Pharm, Dept Organ Chem, Coll Med, PL-30688 Krakow, Poland
[2] Jagiellonian Univ, Fac Chem, Dept Organ Chem, PL-30060 Krakow, Poland
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 45期
关键词：
Cycloaddition; Azides; Alkynes; Copper; Heterocycles; CLICK-CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; POLYMER;
D O I：
10.1016/j.tetlet.2015.09.110
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient procedures for the copper-catalyzed Huisgen cycloaddition reaction in aqueous media were developed using a novel water-soluble catalytic ligand, 2-{4-[(dimethylamino)methyl]-1,2,3-triazol-1-yl)cyclohexan-1-ol (AMTC). A series of aliphatic and aromatic substrates were tested and compared to the well-known tris(triazole)amine ligands (TBTA and THPTA). The effect of solvent composition was also investigated. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6244 / 6247
页数：4
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