A new water-soluble ligand for efficient copper-catalyzed Huisgen cycloaddition of aliphatic azides and alkynes

被引：21

作者：

Szafranski, Przemyslaw W. ^{[1
]}

Kasza, Patryk ^{[1
,2
]}

Cegla, Marek T. ^{[1
]}

机构：

[1] Jagiellonian Univ, Fac Pharm, Dept Organ Chem, Coll Med, PL-30688 Krakow, Poland

[2] Jagiellonian Univ, Fac Chem, Dept Organ Chem, PL-30060 Krakow, Poland

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 45期

关键词：

Cycloaddition; Azides; Alkynes; Copper; Heterocycles; CLICK-CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; POLYMER;

D O I：

10.1016/j.tetlet.2015.09.110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient procedures for the copper-catalyzed Huisgen cycloaddition reaction in aqueous media were developed using a novel water-soluble catalytic ligand, 2-{4-[(dimethylamino)methyl]-1,2,3-triazol-1-yl)cyclohexan-1-ol (AMTC). A series of aliphatic and aromatic substrates were tested and compared to the well-known tris(triazole)amine ligands (TBTA and THPTA). The effect of solvent composition was also investigated. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：6244 / 6247

页数：4

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