Homo- and nor-plakotenin, new carboxylic acids from the Palauan sponge Plakortis lita

被引：17
作者：
Qureshi, A
Stevenson, CS
Albert, CL
Jacobs, RS
Faulkner, DJ [1 ]
机构：
[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA
[2] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 08期
关键词：
D O I：
10.1021/np990164x
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A specimen of Plakortis lita from Palau yielded the new carboxylic acids, homo-plakotenin (2a), the sodium salt of homo-plakotenin (2b), the sodium salt of nor-plakotenin (3), the sodium salt of plakotenin (1b), and the known compound plakotenin (1a). The structures of the new acids were elucidated by interpretation of spectral data and by comparison with the known compound. Compounds 1a, 1b, and 2a were found to significantly reduce proliferation of rheumatoid synovial fibroblasts.
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页码：1205 / 1207
页数：3
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