Monoterpenes with antibacterial activities from a Cameroonian medicinal plant Canthium Multiflorum (Rubiaceae)

被引:13
|
作者
Kouam, Simeon Fogue [1 ]
Ngouonpe, Alain Wembe [1 ]
Bullach, Anke [2 ]
Lamshoeft, Marc [2 ]
Kuigoua, Guy Merlin [1 ,2 ]
Spiteller, Michael [2 ]
机构
[1] Univ Yaounde I, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon
[2] TU Dortmund, Inst Environm Res INFU, Dept Chem & Chem Biol, Chair Environm Chem & Analyt Chem, D-44221 Dortmund, Germany
关键词
Canthium multiflorum; Rubiaceae; Iridoids; Antibacterial; Antiplasmodial; NATURALLY-OCCURRING IRIDOIDS; CONSTITUENTS; GLUCOSIDES;
D O I
10.1016/j.fitote.2013.08.025
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Investigation of the crude extract obtained from the aerial parts of Canthium multiflorum led to the isolation of a new iridoid (1) together with twelve known compounds. The structures of these compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic data, accurate mass measurements and comparison with analytical data of previously known analogues. Most of the isolated compounds have been reported for the first time from C multiflorium. The antimicrobial activities of the isolated compounds were evaluated on five different bacterial strains using agar diffusion technique. The Gram-positive bacterium Staphylococcus aureus subsp. aureus (DSM 799), and the Gram-negative bacteria Actinobacter calco-aceticus (DSM 30006), Serratia plymuthica (DSM 4540), Pseudomonas stutzeri (DSM 4166) and Escherichia coli (DSM 1116) were employed for this purpose. The new iridoid, named 6-oxo-genipin (1), demonstrated significant inhibitory activity against all microbial strains tested, especially the pathogen Staphylococcus aureus. In addition, the compounds 3, 4 and 9 exhibited antiplasmodial activity against Plasmodium falciparum strain 1(1 and weak cytotoxicity against L6 cell lines. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:199 / 204
页数:6
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