The integration of T cell migration, differentiation and function

被引：480

作者：

Masopust, David ^{[1
]}

Schenkel, Jason M. ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CHEMOKINE RECEPTOR CCR7; CD103(+) DENDRITIC CELLS; LYMPH-NODES; CUTTING EDGE; RESIDENT MEMORY; HOMING RECEPTOR; L-SELECTIN; RECIRCULATING LYMPHOCYTES; RM CELLS; TISSUE;

D O I：

10.1038/nri3442

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent activation and differentiation, and their role in the processes of infection control, tumour eradication, autoimmunity, allergy and alloreactivity are intrinsically coupled with migration. Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classification schemes and summarize the heuristic framework provided by viewing T cell differentiation and function first through the prism of migration.

引用

收藏

页码：309 / 320

页数：12

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