Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort

被引：44

作者：

Matejcic, M. ^{[1
]}

de Batlle, J. ^{[1
]}

Ricci, C. ^{[1
]}

Biessy, C. ^{[1
]}

Perrier, F. ^{[1
]}

Huybrechts, I. ^{[1
]}

Weiderpass, E. ^{[2
,3
,4
,6
]}

Boutron-Ruault, M. C. ^{[5
,7
]}

Cadeau, C. ^{[5
,7
]}

His, M. ^{[5
,7
]}

Cox, D. G. ^{[8
]}

Boeing, H. ^{[9
]}

Fortner, R. T. ^{[10
]}

Kaaks, R. ^{[10
]}

Lagiou, P. ^{[11
,12
,13
]}

Trichopoulou, A. ^{[11
,12
]}

Benetou, V. ^{[12
]}

Tumino, R. ^{[14
,15
]}

Panico, S. ^{[16
]}

Sieri, S. ^{[17
]}

Palli, D. ^{[18
]}

Ricceri, F. ^{[19
,20
]}

Bueno-de-Mesquita, H. B ^{[21
,22
,23
]}

Skeie, G. ^{[3
]}

Amiano, P. ^{[24
,25
]}

Sanchez, M. J. ^{[24
,26
]}

Chirlaque, M. D. ^{[24
,27
,28
]}

Barricarte, A. ^{[24
,29
,30
]}

Quiros, J. R. ^{[31
]}

Buckland, G. ^{[32
]}

van Gils, C. H. ^{[33
]}

Peeters, P. H. ^{[33
,34
]}

Key, T. J. ^{[35
]}

Riboli, E. ^{[34
]}

Gylling, B. ^{[36
]}

Zeleniuch-Jacquotte, A. ^{[37
]}

Gunter, M. J. ^{[1
]}

Romieu, I. ^{[1
]}

Chajes, V. ^{[1
]}

机构：

[1] Int Agcy Res Canc, Lyon, France

[2] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[3] Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway

[4] Inst Populat Based Canc Res, Canc Registry Norway, Dept Res, Oslo, Norway

[5] Inst Gustave Roussy, Villejuif, France

[6] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[7] Univ Paris 11, INSERM, Univ Paris Saclay, UVSQ,CESP, Villejuif, France

[8] Canc Res Ctr Lyon, INSERM, Ctr Leon Berard, U1052, Lyon, France

[9] German Inst Human Nutr Potsdam Rehbruecke DIfE, Epidemiol, Nuthetal, Germany

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] Hellen Hlth Fdn, Athens, Greece

[12] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Unit Nutr Epidemiol & Nutr Publ Hlth,WHO Collabor, Athens, Greece

[13] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[15] ASP Ragusa, Civ MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[16] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[17] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy

[20] Reg Hlth Serv ASL TO3, Epidemiol Unit, Grugliasco, Italy

[21] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[22] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[23] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[24] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[25] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[26] Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria Ibs, Escuela Andaluza Salud Publ, Granada, Spain

[27] IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[28] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[29] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[30] Navarra Publ Hlth Inst, Pamplona, Spain

[31] Publ Hlth Directorate, Asturias, Spain

[32] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain

[33] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[34] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[35] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[36] Umea Univ, Dept Med Biosci Pathol, Umea, Sweden

[37] NYU, Sch Med, Dept Populat Hlth, New York, NY 10003 USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2017年 / 140卷 / 06期

基金：

英国医学研究理事会;

关键词：

plasma biomarkers; folate; vitamin B12; alcohol; hormone receptor status; MTHFR polymorphism; breast cancer; ONE-CARBON METABOLISM; DNA METHYLATION; METHYLENETETRAHYDROFOLATE REDUCTASE; MICROBIOLOGICAL ASSAY; POSTMENOPAUSAL WOMEN; MTHFR POLYMORPHISMS; COMMON MUTATION; DIETARY-INTAKE; PLASMA FOLATE; B-VITAMINS;

D O I：

10.1002/ijc.30536

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1=1.26; 95% CI 1.00-1.58; P-trend=0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1=1.29; 95% CI 1.02-162; P-trend=0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.

引用

页码：1246 / 1259

页数：14

共 58 条

[1] Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12) [J].