Effect of GDNF on the Behavior of ASC Mice with High Hereditary Predisposition to Catalepsy

被引：3

作者：

Semenova, A. A. ^{[1
]}

Bazovkina, D. V. ^{[1
]}

Tsybko, A. S. ^{[1
]}

Naumenko, V. S. ^{[1
]}

Popova, N. K. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2013年 / 63卷 / 04期

关键词：

GDNF; dopamine; catalepsy; obsessive-compulsive behavior; locomotor activity; mice; OBSESSIVE-COMPULSIVE DISORDER; NEUROTROPHIC FACTOR; DOPAMINE FUNCTION; SUBSTANTIA-NIGRA; HALOPERIDOL; SEROTONIN;

D O I：

10.7868/S0044467713040102

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ASC mice, which were selected for high predisposition to catalepsy, are convenient genetic model for research of central mechanisms related to disorder of motor regulation. The aim of the work was to study the effect of glial cell line-derived neurotrophic factor (GDNF) on catalepsy, locomotor activity, stereotyping behavior in the marble burying test and on the dopamine level in striatum of ASC mice. It was shown that GDNF increased the locomotor activity in the open field, reduced catalepsy expression and stimulated the stereotyping obsessive-compulsive behavior. These changes in behavior were accompanied by increasing dopamine level in striatum.

引用

页码：495 / 501

页数：7

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