Portable spectroscopic system for in vivo skin neoplasms diagnostics by Raman and autofluorescence analysis

被引：48
|
作者：
Khristoforova, Yulia A. [1 ]
Bratchenko, Ivan A. [1 ]
Myakinin, Oleg O. [1 ]
Artemyev, Dmitry N. [1 ]
Moryatov, Alexander A. [2 ,3 ]
Orlov, Andrey E. [3 ]
Kozlov, Sergey V. [2 ,3 ]
Zakharov, Valery P. [1 ]
机构：
[1] Samara Natl Res Univ, Dept Laser & Biotech Syst, 34 Moskovskoe Shosse, Samara 443086, Russia
[2] Samara State Med Univ, Dept Oncol, Samara, Russia
[3] Samara Reg Clin Oncol Dispensary, Dept Visual Localizat Tumors, Samara, Russia
来源：
JOURNAL OF BIOPHOTONICS | 2019年 / 12卷 / 04期
关键词：
autofluorescence; malignancy; melanoma; optical biopsy; partial least square analysis; portable spectroscopic equipment; Raman spectroscopy; skin neoplasms; NAKED-EYE EXAMINATION; BASAL-CELL CARCINOMA; DISCRIMINATION; MELANOMA; CANCER; DERMOSCOPY; ACCURACY; LESIONS;
D O I：
10.1002/jbio.201800400
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The present paper studies the applicability of a portable cost-effective spectroscopic system for the optical screening of skin tumors. in vivo studies of Raman scattering and autofluorescence (AF) of skin tumors with the 785 nm excitation laser in the near-infrared region included malignant melanoma, basal cell carcinoma and various types of benign neoplasms. The efficiency of the portable system was evaluated by comparison with a highly sensitive spectroscopic system and with the diagnosis accuracy of a human oncologist. Partial least square analysis of Raman and AF spectra was performed; specificity and sensitivity of various skin oncological pathologies detection varied from 78.9% to 100%. Hundred percent accuracy of benign and malignant skin tumors differentiation is possible only with a combined analysis of Raman and AF signals.
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页数：11
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