Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

被引:12
作者
Li, Shuxia [1 ]
Zhu, Huiting [1 ]
机构
[1] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Dept Pathol, Shanghai 200040, Peoples R China
关键词
Cervix; Cytology; Histogenesis; Neuroendocrine carcinoma; ADENOCARCINOMA IN-SITU; GLANDULAR LESIONS; CELL CARCINOMA; IMMUNOPHENOTYPE; EXPRESSION; TUMORS;
D O I
10.1159/000342516
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Objective: Neuroendocrine carcinoma (NEC) of the uterine cervix is a highly aggressive type of tumor. Therefore, recognition of its cytology and histopathology is important for early diagnosis. Study Design: We report 6 cases of small-cell and 6 cases of large-cell NEC of the uterine cervix, including 5 cytology slides. AE1/3, CEA, p63, p16, CD56, chromogranin and synaptophysin were detected. Results: Two cytology slides of small-cell NEC showed sheet-like clusters. The tumor cells were uniformly small, with finely granular chromatin, scant cytoplasm and absent nucleoli. Three large-cell NEC smears showed palisading, molding and abortive rosettes with prominent eosinophilic nucleoli. The tumor cells had either abundant cytoplasm or no cytoplasm at all. The histopathology analysis indicated a transition from dysplasia glands or adenocarcinoma in situ glands to NEC in 6 cases. Conclusion: Cervical cytology of NEC has many unique characteristics, distinct from the characteristics of other lesions. We also demonstrated a hypothesis of the histogenesis of some NECs. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码:54 / 60
页数:7
相关论文
共 20 条
[11]   Intestinal-type cervical adenocarcinoma In situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2 [J].
McCluggage, W. G. ;
Shah, R. ;
Connolly, L. E. ;
McBride, H. A. .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2008, 27 (01) :92-100
[12]   An Immunohistochemical Study of Cervical Neuroendocrine Carcinomas: Neoplasms That are Commonly TTF1 Positive and Which May Express CK20 and P63 [J].
McCluggage, W. Glenn ;
Kennedy, Kathryn ;
Busam, Klaus J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2010, 34 (04) :525-532
[13]   Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum' [J].
Mikami, Y ;
Kyokawa, T ;
Hata, S ;
Fujiwara, K ;
Moriya, T ;
Sasano, H ;
Manabe, T ;
Akahira, JI ;
Ito, K ;
Tase, T ;
Yaegashi, N ;
Sato, I ;
Tateno, H ;
Naganuma, H .
MODERN PATHOLOGY, 2004, 17 (08) :962-972
[14]  
Niwa K, 2010, ACTA CYTOL, V54, P977
[15]   Differential expression of MUC2 and MUC5AC in benign and malignant glandular lesions of the cervix uteri [J].
Riethdorf, L ;
O'Connell, JT ;
Riethdorf, S ;
Cviko, A ;
Crum, CP .
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 2000, 437 (04) :365-371
[16]   Endocervical Adenocarcinomas With Ovarian Metastases Analysis of 29 Cases With Emphasis on Minimally Invasive Cervical Tumors and the Ability of the Metastases to Simulate Primary Ovarian Neoplasms [J].
Ronnett, Brigitte M. ;
Yemelyanova, Anna V. ;
Vang, Russell ;
Gilks, C. Blake ;
Miller, Dianne ;
Gravitt, Patti E. ;
Kurman, Robert J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2008, 32 (12) :1835-1853
[17]   Large cell neuroendocrine carcinoma of the uterine cervix: A clinicopathological study of six cases [J].
Sato, Y ;
Shimamoto, T ;
Amada, S ;
Asada, Y ;
Hayashi, T .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2003, 22 (03) :226-230
[18]   Utility of the monoclonal antibody HIK1083 in the diagnosis of adenoma malignum of the uterine cervix [J].
Utsugi, K ;
Hirai, Y ;
Takeshima, N ;
Akiyama, F ;
Sakurai, S ;
Hasumi, K .
GYNECOLOGIC ONCOLOGY, 1999, 75 (03) :345-348
[19]   Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence [J].
Viswanathan, AN ;
Deavers, MT ;
Jhingran, A ;
Ramirez, PT ;
Levenback, C ;
Eifel, PJ .
GYNECOLOGIC ONCOLOGY, 2004, 93 (01) :27-33
[20]  
Wells etal., 2003, World Health Organization of Tumours, P262