Protein tyrosine phosphatases in health and disease

被引：127

作者：

Hendriks, Wiljan J. A. J. ^{[1
]}

Elson, Ari ^{[2
]}

Harroch, Sheila ^{[3
]}

Pulido, Rafael ^{[4
]}

Stoker, Andrew ^{[5
]}

den Hertog, Jeroen ^{[6
,7
,8
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[2] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[3] Inst Pasteur, Dept Neurosci, Paris, France

[4] Ctr Invest Principe Felipe, Valencia, Spain

[5] UCL, Inst Child Hlth, Neural Dev Unit, London WC1E 6BT, England

[6] KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[7] Univ Med Ctr Utrecht, Utrecht, Netherlands

[8] Leiden Univ, Inst Biol Leiden, NL-2300 RA Leiden, Netherlands

来源：

FEBS JOURNAL | 2013年 / 280卷 / 02期

关键词：

bone morphogenesis; hereditary disease; neuronal development; post-translational modification; protein tyrosine phosphatase; synaptogenesis; NF-KAPPA-B; MAP KINASE PHOSPHATASES; SRC-FAMILY KINASES; RECEPTOR-TYPE-Z; SYNAPSE FORMATION; PTP-SIGMA; AMPA RECEPTOR; OSTEOCLAST FUNCTION; GENE-EXPRESSION; CELL;

D O I：

10.1111/febs.12000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.

引用

页码：708 / 730

页数：23

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