Involvement of Nervous System Pathways in Primary Sjogren's Syndrome

被引：30

作者：

Segal, Barbara ^{[1
]}

Carpenter, Adam ^{[2
]}

Walk, David ^{[2
]}

机构：

[1] Univ Minnesota, Sch Med, Div Rheumat & Autoimmune Disorders, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Neurol, Minneapolis, MN 55455 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2008年 / 34卷 / 04期

关键词：

Sjogren's syndrome; Neurologic disorders;

D O I：

10.1016/j.rdc.2008.08.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A wide range of central and peripheral nervous system disorders occur in patients with primary Sjogren's syndrome (pSS), although the true prevalence is an aspect which has been and remains controversial. Under-recognition of pSS and lack of consensus regarding criteria contribute to the uncertainty regarding the extent of neuropsychiatric involvement. A relatively high rate of affective and cognitive symptoms, as well as abnormal fatigue and poorly characterized pain, are features of pSS that contribute to diminishing health quality in the pSS population. This article describes the neurologic complications and controversies that surround the neurologic syndromes associated with pSS and reviews the current literature on potential immunopathogenetic mechanisms and therapy.

引用

页码：885 / +

页数：23

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