Industrial Applications of the Diels-Alder Reaction

被引：240
作者：
Funel, Jacques-Alexis [1 ]
Abele, Stefan [1 ]
机构：
[1] Actel Pharmaceut Ltd, Proc Res Chem, CH-4123 Allschwil, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 14期
关键词：
cycloaddition; DielsAlder reaction; industrial chemistry; process chemistry; synthetic methods; RESEARCH-AND-DEVELOPMENT; GAMMA-SECRETASE INHIBITORS; VITAMIN-D ANALOGS; ENANTIOSELECTIVE SYNTHESIS; KEY INTERMEDIATE; LARGE-SCALE; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; RECEPTOR ANTAGONIST; EFFICIENT SYNTHESIS;
D O I：
10.1002/anie.201201636
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The DielsAlder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large-scale applications (>1kg) from a process research and development perspective.
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收藏
页码：3822 / 3863
页数：42
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