Indometacin loading and in vitro release properties from novel carbopol coated spherical mesoporous silica nanoparticles

被引：44

作者：

Tzankov, Borislav ^{[1
]}

Yoncheva, Krassimira ^{[1
]}

Popova, Margarita ^{[2
]}

Szegedi, Agnes ^{[3
]}

Momekov, Georgi ^{[1
]}

Mihaly, Judith ^{[3
]}

Lambov, Nicolai ^{[1
]}

机构：

[1] Fac Pharm, Sofia 1000, Bulgaria

[2] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[3] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Mat & Environm Chem, H-1025 Budapest, Hungary

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2013年 / 171卷

关键词：

Spherical mesoporous silica; Indometacin release; Carbopol coating; Cytotoxicity; CONTROLLED DRUG-RELEASE; ANTIINFLAMMATORY DRUG; DELIVERY-SYSTEM; FUNCTIONALIZATION; CARRIERS; MCM-41; MORPHOLOGY; MATRICES; MOLECULES; INJURY;

D O I：

10.1016/j.micromeso.2012.12.037

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Spherical MCM-41 silica nanosized particles were synthesized and post synthesis modified by 3-amino-propyltriethoxysilane (APTES) in order to prepare amino-functionalized carrier. Both types of silica particles were loaded with indometacin and further coated with carbopol. The preservation of morphology and pore structure of the particles was observed by XRD, TEM and N-2 physisorption. FTIR spectroscopy revealed the interaction between carboxyl groups of indometacin and the amino groups of the functionalized MCM-41. Amino-functionalization of the carrier resulted in higher degree of indometacin loading in comparison to the parent MCM-41, 39% vs. 30%, respectively. The coating of drug loaded amino-MCM-41 silica particles with carbopol significantly reduced the initial burst release of indometacin. Both silica carriers demonstrated no cytotoxicity on HL-60 (acute myeloid leukemia) and K-562 (chronic myeloid leukemia) cell lines. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：131 / 138

页数：8

共 30 条

[1] Functionalized silica matrices for controlled delivery of cephalexin [J].