Frequency of five unusual presentations in patients with COVID-19: results of the UMC-19-S1

Despite SARS-CoV-19 infection has a stereotypical clinical picture, isolated cases with unusual manifestations have been reported, some of them being well-known to be triggered by viral infections. However, the real frequency in COVID-19 is unknown. Analysing data of 63 822 COVID patients attending 50 Spanish emergency department (ED) during the COVID outbreak, before hospitalisation, we report frequencies of (myo)pericarditis (0.71 parts per thousand), meningoencephalitis (0.25 parts per thousand), Guillain-Barre syndrome (0.13 parts per thousand), acute pancreatitis (0.71 parts per thousand) and spontaneous pneumothorax (0.57 parts per thousand). Compared with general ED population, COVID patients developed more frequently Guillain-Barre syndrome (odds ratio (OR) 4.55, 95% confidence interval (CI) 2.09-9.90), spontaneous pneumothorax (OR 1.98, 95% CI 1.40-2.79) and (myo)pericarditis (OR 1.45, 95% CI 1.07-1.97), but less frequently pancreatitis (OR 0.44, 95% CI 0.33-0.60).