Novel euglycemic and hypolipidemic agents: Pyridine containing unsaturated thiazolidinediones

被引：0
作者：
Lohray, BB [1 ]
Bhushan, V [1 ]
Reddy, AS [1 ]
Rao, PB [1 ]
Reddy, NJ [1 ]
Reddy, KA [1 ]
Vikramadithyan, RK [1 ]
Rajagopalan, R [1 ]
机构：
[1] Dr Reddys Res Fdn, Dept Med Chem & Drug Discovery, Hyderabad 500050, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1999年 / 38卷 / 04期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyridyl containing 2,4-thiazolidinediones having cyclic amine as linker have been synthesized. Both unsaturated thiazolidinedione 6 and saturated thiazolidinedione 5 and their various salts have been evaluated in db/db mice for euglycemic and hypolipidemic effects. The maleate salt of TZD 6a is found to be a very potent euglycemic and hypolipidemic compound.
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页码：403 / 406
页数：4
相关论文
共 15 条
  • [1] THE SYNTHESIS OF BRL-49653 - A NOVEL AND POTENT ANTIHYPERGLYCEMIC AGENT
    CANTELLO, BCC
    CAWTHORNE, MA
    HAIGH, D
    HINDLEY, RM
    SMITH, SA
    THURLBY, PL
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (10) : 1181 - 1184
  • [2] [[OMEGA-(HETEROCYCLYLAMINO)ALKOXY]BENZYL]-2,4-THIAZOLIDINEDIONES AS POTENT ANTIHYPERGLYCEMIC AGENTS
    CANTELLO, BCC
    CAWTHORNE, MA
    COTTAM, GP
    DUFF, PT
    HAIGH, D
    KINDLEY, RM
    LISTER, CA
    SMITH, SA
    THURLBY, PL
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) : 3977 - 3985
  • [3] EFFECT OF NEAR NORMOGLYCEMIA FOR 2 YEARS ON PROGRESSION OF EARLY DIABETIC-RETINOPATHY, NEPHROPATHY, AND NEUROPATHY - THE OSLO STUDY
    DAHLJORGENSEN, K
    BRINCHMANNHANSEN, O
    HANSSEN, KF
    GANES, T
    KIERULF, P
    SMELAND, E
    SANDVIK, L
    AAGENAES, O
    [J]. BRITISH MEDICAL JOURNAL, 1986, 293 (6556) : 1195 - 1199
  • [4] THE TRIUMVIRATE - BETA-CELL, MUSCLE, LIVER - A COLLUSION RESPONSIBLE FOR NIDDM
    DEFRONZO, RA
    [J]. DIABETES, 1988, 37 (06) : 667 - 687
  • [5] FELDTRASMUSSEN B, 1986, LANCET, V2, P1300
  • [6] 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR-GAMMA
    FORMAN, BM
    TONTONOZ, P
    CHEN, J
    BRUN, RP
    SPIEGELMAN, BM
    EVANS, RM
    [J]. CELL, 1995, 83 (05) : 803 - 812
  • [7] REDUCTION OF INSULIN RESISTANCE IN OBESE AND OR DIABETIC ANIMALS BY 5-[4-(1-METHYLCYCLOHEXYLMETHOXY)BENZYL]-THIAZOLIDINE-2,4-DIONE (ADD-3878, U-63,287, CIGLITAZONE), A NEW ANTI-DIABETIC AGENT
    FUJITA, T
    SUGIYAMA, Y
    TAKETOMI, S
    SOHDA, T
    KAWAMATSU, Y
    IWATSUKA, H
    SUZUOKI, Z
    [J]. DIABETES, 1983, 32 (09) : 804 - 810
  • [8] Novel euglycemic and hypolipidemic agents. 1
    Lohray, BB
    Bhusan, V
    Rao, BP
    Medhavan, GR
    Murali, N
    Rao, KN
    Reddy, AK
    Rajesh, BM
    Reddy, PG
    Chakrabarti, R
    Vikramadithyan, RK
    Rajagopalan, R
    Mamidi, RNVS
    Jajoo, HK
    Subramanian, S
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (10) : 1619 - 1630
  • [9] Novel indole containing thiazolidinedione derivatives as potent euglycemic and hypolipidaemic agents
    Lohray, BB
    Bhushan, V
    Rao, PB
    Madhavan, GR
    Murali, N
    Rao, KN
    Reddy, KA
    Rajesh, BM
    Reddy, PG
    Chakrabarti, R
    Rajagopalan, R
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (07) : 785 - 788
  • [10] Increase of lipoprotein (a) with troglitazone
    Matsumoto, K
    Miyake, S
    Yano, M
    Ueki, Y
    Tominaga, Y
    [J]. LANCET, 1997, 350 (9093) : 1748 - 1749
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