White fat progenitor cells reside in the adipose vasculature

被引：842

作者：

Tang, Wei ^{[1
]}

Zeve, Daniel ^{[1
]}

Suh, Jae Myoung ^{[1
]}

Bosnakovski, Darko ^{[1
]}

Kyba, Michael ^{[1
]}

Hammer, Robert E. ^{[2
]}

Tallquist, Michelle D. ^{[3
]}

Graff, Jonathan M. ^{[1
,3
,4
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

来源：

SCIENCE | 2008年 / 322卷 / 5901期

关键词：

D O I：

10.1126/science.1156232

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.

引用

页码：583 / 586

页数：4

共 28 条

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