Angiosarcoma in HIV-negative patients is not associated with HHV-8

被引：2
|
作者：
Avancini, Joao [1 ]
Zanata Cherubim, Andre Pires [1 ]
de Oliveira, Cristina Mendes [1 ]
Sakai Valente, Neusa Yuriko [1 ]
Festa Neto, Cyro [1 ]
Sanches, Jose Antonio [1 ]
Pazzini, Renato [1 ]
Sumita, Laura Masami [1 ]
Pannuti, Claudio Sergio [1 ]
机构：
[1] Univ Sao Paulo, Sao Paulo, SP, Brazil
来源：
ANAIS BRASILEIROS DE DERMATOLOGIA | 2016年 / 91卷 / 06期
关键词：
Hemangiosarcoma; Herpesvirus; 8; human; HIV; SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; DNA-SEQUENCES; HUMAN-HERPESVIRUS-8; DNA; ABSENCE; INFECTION; LESIONS; KSHV; POPULATIONS; TUMORS;
D O I：
10.1590/abd1806-4841.20164730
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls. RESULTS: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was. CONCLUSION: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
引用
收藏
页码：738 / 741
页数：4
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