Angiosarcoma in HIV-negative patients is not associated with HHV-8

被引：2

作者：

Avancini, Joao ^{[1
]}

Zanata Cherubim, Andre Pires ^{[1
]}

de Oliveira, Cristina Mendes ^{[1
]}

Sakai Valente, Neusa Yuriko ^{[1
]}

Festa Neto, Cyro ^{[1
]}

Sanches, Jose Antonio ^{[1
]}

Pazzini, Renato ^{[1
]}

Sumita, Laura Masami ^{[1
]}

Pannuti, Claudio Sergio ^{[1
]}

机构：

[1] Univ Sao Paulo, Sao Paulo, SP, Brazil

来源：

ANAIS BRASILEIROS DE DERMATOLOGIA | 2016年 / 91卷 / 06期

关键词：

Hemangiosarcoma; Herpesvirus; 8; human; HIV; SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; DNA-SEQUENCES; HUMAN-HERPESVIRUS-8; DNA; ABSENCE; INFECTION; LESIONS; KSHV; POPULATIONS; TUMORS;

D O I：

10.1590/abd1806-4841.20164730

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls. RESULTS: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was. CONCLUSION: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.

引用

页码：738 / 741

页数：4

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