Melanocortin-4 receptors, β-MSH and leptin:: Key elements in the satiety pathway

被引：40
|
作者：
Harrold, JA [1 ]
Williams, G [1 ]
机构：
[1] Univ Liverpool, Dept Med, Neuroendocrine & Obes Biol Unit, Liverpool L69 3GA, Merseyside, England
来源：
PEPTIDES | 2006年 / 27卷 / 02期
关键词：
MC4R; hypothalamus; dietary obesity; beta-MSH; leptin; insulin;
D O I：
10.1016/j.peptides.2005.01.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4 receptor (MC4R) regulation with altered nutritional status, the role of MC4R in dietary obesity and the identity of the endogenous MC4R ligand. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：365 / 371
页数：7
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