The total synthesis of the fungal metabolite diversonol

被引：83
|
作者：
Nising, CF [1 ]
Ohnemüller, UK [1 ]
Bräse, S [1 ]
机构：
[1] Univ Karlsruhe, Inst Organ Chem, D-76131 Karlsruhe, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 02期
关键词：
diversonol; domino reactions; fungal metabolites; natural products; total synthesis;
D O I：
10.1002/anie.200502913
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Mission accomplished. The fungal metabolite diversonol has been synthesized for the first time. A key step in the total synthesis was the domino oxa-Michael-aldol condensation of salicylic aldehyde 1 and 4-hydroxycyclohexenone (2) that afforded the tricyclic scaffold of the target compound. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：307 / 309
页数：3
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