Clinical implications of the global multidrug-resistant tuberculosis epidemic

被引：2

作者：

Kumar, Kartik ^{[1
,2
]}

Abubakar, Ibrahim ^{[3
,4
]}

机构：

[1] UCL, Ctr Infect Dis Epidemiol, Res Dept Infect & Populat Hlth, London, England

[2] Whittington Hosp NHS Trust, Whittington Hlth, London, England

[3] UCL, Infect Dis Epidemiol, Ctr Infect Dis Epidemiol, London, England

[4] UCL, MRC Clin Trials Unit, London, England

来源：

CLINICAL MEDICINE | 2016年 / 16卷 / 06期

关键词：

Multidrug-resistant tuberculosis; epidemiology; diagnostics; treatment; LINE PROBE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; RIFAMPICIN RESISTANCE; XPERT MTB/RIF; PULMONARY TUBERCULOSIS; RAPID DETECTION; DELAMANID; IMPACT; METAANALYSIS;

D O I：

10.7861/clinmedicine.16-6-565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multidrug-resistant tuberculosis (MDR TB) is a significant threat to global health estimated to account for nearly half a million new cases and over 200,000 deaths in 2013. The number of MDR TB cases in the UK has risen over the last 15 years, with ever more complex clinical cases and associated challenging public health and societal implications. In this review, we provide an overview of the epidemiology of MDR TB globally and in the UK, outline the clinical management of MDR TB and summarise recent advances in diagnostics and prospects for new treatment.

引用

页码：565 / 570

页数：6

共 35 条

[1] Tuberculosis 2013:5 Drug-resistant tuberculosis: time for visionary political leadership [J].

Abubakar, Ibrahim ;

Zignol, Matteo ;

Falzon, Dennis ;

Raviglione, Mario ;

Ditiu, Lucica ;

Masham, Susan ;

Adetifa, Lfedayo ;

Ford, Nathan ;

Cox, Helen ;

Lawn, Stephen D. ;

Marais, Ben J. ;

McHugh, Timothy D. ;

Mwaba, Peter ;

Bates, Matthew ;

Lipman, Marc ;

Zijenah, Lynn ;

Logan, Simon ;

McNerney, Ruth ;

Zumla, Adam ;

Sarda, Krishna ;

Nahid, Payam ;

Hoelscher, Michael ;

Pletschette, Michel ;

Memish, Ziad A. ;

Kim, Peter ;

Hafner, Richard ;

Cole, Stewart ;

Migliori, Giovanni Battista ;

Maeurer, Markus ;

Schito, Marco ;

Zumla, Alimuddin .

LANCET INFECTIOUS DISEASES, 2013, 13 (06) :529-539

[2] A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis [J].

Andries, K ;

Verhasselt, P ;

Guillemont, J ;

Göhlmann, HWH ;

Neefs, JM ;

Winkler, H ;

Van Gestel, J ;

Timmerman, P ;

Zhu, M ;

Lee, E ;

Williams, P ;

de Chaffoy, D ;

Huitric, E ;

Hoffner, S ;

Cambau, E ;

Truffot-Pernot, C ;

Lounis, N ;

Jarlier, V .

SCIENCE, 2005, 307 (5707) :223-227

[3]

[Anonymous], 2013, The use of Bedaquiline in the treatment of m ultidrug-resistant tuberculosis. Interim policy guidance

[4]

[Anonymous], 2014, DEF REP FRAM TUB 201

[5]

[Anonymous], TUBERCLE S

[6] RAPID DETECTION OF RIFAMPICIN RESISTANCE IN SPUTUM AND BIOPSY SPECIMENS FROM TUBERCULOSIS PATIENTS BY PCR AND LINE PROBE ASSAY [J].

DEBEENHOUWER, H ;

LHIANG, Z ;

JANNES, G ;

MIJS, W ;

MACHTELINCKX, L ;

ROSSAU, R ;

TRAORE, H ;

PORTAELS, F .

TUBERCLE AND LUNG DISEASE, 1995, 76 (05) :425-430

[7] Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients [J].

Diacon, A. H. ;

Dawson, R. ;

Hanekom, M. ;

Narunsky, K. ;

Venter, A. ;

Hittel, N. ;

Geiter, L. J. ;

Wells, C. D. ;

Paccaly, A. J. ;

Donald, P. R. .

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2011, 15 (07) :949-954

[8] Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline [J].

Diacon, Andreas H. ;

Pym, Alexander ;

Grobusch, Martin P. ;

de los Rios, Jorge M. ;

Gotuzzo, Eduardo ;

Vasilyeva, Irina ;

Leimane, Vaira ;

Andries, Koen ;

Bakare, Nyasha ;

De Marez, Tine ;

Haxaire-Theeuwes, Myriam ;

Lounis, Nacer ;

Meyvisch, Paul ;

De Paepe, Els ;

van Heeswijk, Rolf P. G. ;

Dannemann, Brian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (08) :723-732

[9] Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis [J].

Drobniewski, Francis ;

Cooke, Mary ;

Jordan, Jake ;

Casali, Nicola ;

Mugwagwa, Tendai ;

Broda, Agnieszka ;

Townsend, Catherine ;

Sivaramakrishnan, Anand ;

Green, Nathan ;

Jit, Mark ;

Lipman, Marc ;

Lord, Joanne ;

White, Peter J. ;

Abubakar, Ibrahim .

HEALTH TECHNOLOGY ASSESSMENT, 2015, 19 (34) :1-+

[10]

European Medicines Agency, 2013, EUR MED AG REC 2 NEW

← 1 2 3 4 →