Exploring the full spectrum of macrophage activation

被引：6926
作者：
Mosser, David M. [1 ]
Edwards, Justin P.
机构：
[1] Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri2448
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities-host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.
引用
收藏
页码：958 / 969
页数：12
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