Natural photoswitches expose STIM1 activation steps

被引：2

作者：

Derler, Isabella ^{[1
]}

Romanin, Christoph ^{[1
]}

机构：

[1] Johannes Kepler Univ Linz, Inst Biophys, Gruberstr 40, A-4020 Linz, Austria

来源：

CELL CALCIUM | 2020年 / 90卷

基金：

奥地利科学基金会;

关键词：

CRAC channel; Optogenetic engineering; STIM1; ORAI1;

D O I：

10.1016/j.ceca.2020.102240

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

STIM1, an ER-located Ca2+ sensor, activates Orai1 channels upon Ca2+-storedepletion. Prior to this, STIM1 undergoes a sequence of conformational changes, which cannot be controlled individually with high spatio-temporal resolution. Ma et al. [1] used the power of optogenetic engineering to transfer light-sensitivity to STIM1 and precisely characterize individual STIM1 activation steps.

引用

页数：3

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