Natural photoswitches expose STIM1 activation steps

被引：2
|
作者：
Derler, Isabella [1 ]
Romanin, Christoph [1 ]
机构：
[1] Johannes Kepler Univ Linz, Inst Biophys, Gruberstr 40, A-4020 Linz, Austria
来源：
CELL CALCIUM | 2020年 / 90卷
基金：
奥地利科学基金会;
关键词：
CRAC channel; Optogenetic engineering; STIM1; ORAI1;
D O I：
10.1016/j.ceca.2020.102240
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
STIM1, an ER-located Ca2+ sensor, activates Orai1 channels upon Ca2+-storedepletion. Prior to this, STIM1 undergoes a sequence of conformational changes, which cannot be controlled individually with high spatio-temporal resolution. Ma et al. [1] used the power of optogenetic engineering to transfer light-sensitivity to STIM1 and precisely characterize individual STIM1 activation steps.
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页数：3
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