Feasibility of focal transcranial DC polarization with simultaneous EEG recording: Preliminary assessment in healthy subjects and human epilepsy

被引：60

作者：

Faria, Paula ^{[1
,2
]}

Fregni, Felipe ^{[3
,4
]}

Sebastiao, Fernando ^{[2
,5
]}

Dias, Ana I. ^{[6
]}

Leal, Alberto ^{[7
]}

机构：

[1] Polytech Inst Leiria, Ctr Rapid & Sustainable Prod Dev, Leiria, Portugal

[2] Polytech Inst Leiria, Sch Technol & Management, Leiria, Portugal

[3] Harvard Univ, Sch Med, Spaulding Rehabil Hosp, Lab Neuromodulat, Boston, MA USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[5] Univ Tras Os Montes & Alto Douro, Ctr Math, CM UTAD, Vila Real, Portugal

[6] Hosp Dona Estefania, Dept Pediat Neurol, Lisbon, Portugal

[7] Ctr Hosp Psiquiatr Lisboa, Dept Neurophysiol, Lisbon, Portugal

来源：

EPILEPSY & BEHAVIOR | 2012年 / 25卷 / 03期

关键词：

EEG; tDCS; Polarization; Epilepsy; Transcranial; Safety; DIRECT-CURRENT STIMULATION; HUMAN MOTOR CORTEX; POLARIZING CURRENTS; BRAIN POLARIZATION; CEREBRAL CORTEX; CLINICAL-TRIAL; EXCITABILITY; TDCS; RAT;

D O I：

10.1016/j.yebeh.2012.06.027

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We aimed to investigate the feasibility of an experimental system for simultaneous transcranial DC stimulation (tDCS) and EEG recording in human epilepsy. We report tolerability of this system in a cross-over controlled trial with 15 healthy subjects and preliminary effects of its use, testing repeated tDCS sessions, in two patients with drug-refractory Continuous Spike-Wave Discharges During Slow Sleep (CSWS). Our system combining continuous recording of the EEG with tDCS allows detailed evaluation of the interictal activity during the entire process. Stimulation with 1 mA was well-tolerated in both healthy volunteers and patients with refractory epilepsy. The large reduction in interictal epileptiform EEG discharges in the two subjects with epilepsy supports further investigation of tDCS using this combined method of stimulation and monitoring in epilepsy. Continuous monitoring of epileptic activity throughout tDCS improves safety and allows detailed evaluation of epileptic activity changes induced by tDCS in patients. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：417 / 425

页数：9

共 31 条

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Arzimanoglou A., 2004, Aicardi's Epilepsy in children. 3.A Edicao

[2] ACTION OF BRIEF POLARIZING CURRENTS ON CEREBRAL CORTEX OF RAT .1. DURING CURRENT FLOW + .2. IN PRODUCTION OF LONG-LECTING AFTER-EFFECTS [J].