miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1

被引：13

作者：

Wang, Fakai ^{[1
]}

Zhang, Huanjun ^{[2
]}

Liu, Bing ^{[3
]}

Liu, Wei ^{[3
]}

Zhang, Zengchao ^{[4
]}

机构：

[1] Sunshine Union Hosp Shandong Prov, Brain Ctr, Weifang 261000, Peoples R China

[2] Weifang Maternal & Child Hlth Hosp, Dept Anesthesiol, Weifang 261000, Peoples R China

[3] Weifang Med Univ, Dept Neurosurg, Affiliated Hosp, Weifang 261000, Peoples R China

[4] Weifang Chinese Med Hosp, Dept Neurosurg, Weifang 261000, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2020年 / 2020卷

关键词：

PHOSPHOGLYCERATE KINASE 1; MICRORNA; EPIDEMIOLOGY; GLYCOLYSIS; FAMILY;

D O I：

10.1155/2020/9752372

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. This study is aimed at evaluating its modifying effects on glioma. Significantly decreased expression of miR-6869-5p was found in glioma tissues and cells. Negative association was documented between miR-6869-5p and PGK1 in glioma cells, and PGK1 was demonstrated to be a targeted gene of this miRNA by luciferase reporter assay. miR-6869-5p regulated glioma cell proliferation and invasion via targeting PGK1. In addition, the survival analysis had suggested that low miR-6869-5p expression predicted poor prognosis of glioma patients. This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma.

引用

页数：8

共 50 条

[31] MIR-376-5P INHIBITS PROSTATE CANCER CELL PROLIFERATION AND INDUCES APOPTOSIS BY TARGETING TCTN1
Cheng, Huan
Chen, Yue
Xue, Song
Wen, Rumin
Chen, Jiacun
Wang, Junqi
ACTA MEDICA MEDITERRANEA, 2021, 37 (04): : 2169 - 2175
[32] miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma
Yan, Jing-Jun
Chang, Ying
Zhang, Yu-Nan
Lin, Ju-Sheng
He, Xing-Xing
Huang, Huan-Jun
ONCOLOGY LETTERS, 2017, 13 (05) : 3118 - 3126
[33] miR-218 inhibits the tumorgenesis and proliferation of glioma cells by targeting Robo1
Gu, Jian-Jun
Gao, Guang-Zhong
Zhang, Shi-Ming
CANCER BIOMARKERS, 2016, 16 (03) : 309 - 317
[34] miR-671-5p inhibits gastric cancer cell proliferation and promotes cell apoptosis by targeting URGCP
Qiu, Tiefeng
Wang, Keping
Li, Xianwen
Jin, Jianhua
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) : 4753 - 4758
[35] MiR-331-5p suppresses gastric cancer cell proliferation, migration, invasion, and glycolysis via targeting PFKFB3
Deng, Zhongmin
Wei, Guijun
Qiu, Lei
Lu, Huifei
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 19 (11) : 2265 - 2272
[36] RETRACTED: MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2 (Retracted Article)
Jiang, Tiechao
Sui, Dongming
You, Dong
Yao, Songmei
Zhang, Lirong
Wang, Yingjian
Zhao, Jixue
Zhang, Yaozhong
CELL CYCLE, 2018, 17 (10) : 1268 - 1278
[37] miR-202-5p inhibits the migration and invasion of osteosarcoma cells by targeting ROCK1
Li, Congda
Ma, Deying
Yang, Jinhu
Lin, Xiangbo
Chen, Bo
ONCOLOGY LETTERS, 2018, 16 (01) : 829 - 834
[38] MiR-506-3p inhibits proliferation and invasion by targeting EZH2 in glioblastomas
Deng, Yanyao
Xiao, Le
Liu, Chao
Li, Yuan
Guo, Ziqing
Xie, Bing
Jin, Ziqi
Lv, Zhicheng
Zhu, Hongwei
Wang, Aimin
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (04): : 3726 - 3733
[39] Downregulation of hsa-miR-135b-5p Inhibits Cell Proliferation, Migration, and Invasion in Colon Adenocarcinoma
Zhang, Yunxin
Zhang, Wentao
Xia, Wenlong
Xia, Junwei
Zhang, Haishan
GENETICS RESEARCH, 2022, 2022
[40] MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2
Luo, Chonglin
Merz, Patrick R.
Chen, Yiwei
Dickes, Elke
Pscherer, Armin
Schadendorf, Dirk
Eichmueller, Stefan B.
CANCER LETTERS, 2013, 341 (02) : 240 - 247

← 1 2 3 4 5 →