miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1

被引：13
|
作者：
Wang, Fakai [1 ]
Zhang, Huanjun [2 ]
Liu, Bing [3 ]
Liu, Wei [3 ]
Zhang, Zengchao [4 ]
机构：
[1] Sunshine Union Hosp Shandong Prov, Brain Ctr, Weifang 261000, Peoples R China
[2] Weifang Maternal & Child Hlth Hosp, Dept Anesthesiol, Weifang 261000, Peoples R China
[3] Weifang Med Univ, Dept Neurosurg, Affiliated Hosp, Weifang 261000, Peoples R China
[4] Weifang Chinese Med Hosp, Dept Neurosurg, Weifang 261000, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2020年 / 2020卷
关键词：
PHOSPHOGLYCERATE KINASE 1; MICRORNA; EPIDEMIOLOGY; GLYCOLYSIS; FAMILY;
D O I：
10.1155/2020/9752372
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma. miR-6869-5p has been documented to be aberrantly expressed in diverse cancers. However, the precise role of miR-6869-5p in glioma remains poorly understood. This study is aimed at evaluating its modifying effects on glioma. Significantly decreased expression of miR-6869-5p was found in glioma tissues and cells. Negative association was documented between miR-6869-5p and PGK1 in glioma cells, and PGK1 was demonstrated to be a targeted gene of this miRNA by luciferase reporter assay. miR-6869-5p regulated glioma cell proliferation and invasion via targeting PGK1. In addition, the survival analysis had suggested that low miR-6869-5p expression predicted poor prognosis of glioma patients. This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma.
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页数：8
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