COVID-19 mRNA vaccine-induced adverse effects: unwinding the unknowns

被引:3
作者
Trougakos, Ioannis P. [1 ]
Terpos, Evangelos [2 ]
Alexopoulos, Harry [1 ]
Politou, Marianna [3 ]
Paraskevis, Dimitrios [4 ]
Scorilas, Andreas [5 ]
Kastritis, Efstathios [2 ]
Andreakos, Evangelos [6 ]
Dimopoulos, Meletios A. [2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Dept Cell Biol & Biophys, Fac Biol, Athens 15784, Greece
[2] Natl & Kapodistrian Univ Athens, Sch Med, Alexandra Gen Hosp, Dept Clin Therapeut, Athens 11528, Greece
[3] Natl & Kapodistrian Univ Athens, Sch Med, Aretaieio Hosp, Hematol Lab Blood Bank, Athens 11528, Greece
[4] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11527, Greece
[5] Natl & Kapodistrian Univ Athens, Dept Biochem & Mol Biol, Fac Biol, Athens 15701, Greece
[6] Acad Athens, Biomed Res Fdn, Ctr Clin, Immunobiol Lab, Athens 11527, Greece
关键词
D O I
10.1016/j.molmed.2022.07.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We appreciate the efforts of Cosentino and Marino in reviewing and commenting [1] on our recent opinion article on the putative role of the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines-produced antigen - that is, SARS-CoV-2 Wuhan-Hu-1 strain spike (S) protein - in reported adverse effects (AEs) of vaccination [2]. Cosentino and Marino attempted to answer one of our `outstanding questions' ( sixth question in [2]), and they have introduced an additional issue while also providing a plausible answer. We are responding here to the discussion by adding further perspectives to their arguments.
引用
收藏
页码:800 / 802
页数:3
相关论文
共 12 条
[1]  
Andersson Monique I, 2020, Wellcome Open Res, V5, P181, DOI 10.12688/wellcomeopenres.16002.2
[2]   The spike hypothesis in vaccine-induced adverse effects: questions and answers [J].
Cosentino, Marco ;
Marino, Franca .
TRENDS IN MOLECULAR MEDICINE, 2022, 28 (10) :797-799
[3]   Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral [J].
Dittmayer, Carsten ;
Meinhardt, Jenny ;
Radbruch, Helena ;
Radke, Josefine ;
Heppner, Barbara Ingold ;
Heppner, Frank L. ;
Stenzel, Werner ;
Holland, Gudrun ;
Laue, Michael .
LANCET, 2020, 396 (10260) :E64-E65
[4]   Updated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Estimates Based on Blood Donations, July 2020-December 2021 [J].
Jones, Jefferson M. ;
Opsomer, Jean D. ;
Stone, Mars ;
Benoit, Tina ;
Ferg, Robyn A. ;
Stramer, Susan L. ;
Busch, Michael P. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 328 (03) :298-301
[5]   Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California [J].
Lewnard, Joseph A. ;
Hong, Vennis X. ;
Patel, Manish M. ;
Kahn, Rebecca ;
Lipsitch, Marc ;
Tartof, Sara Y. .
NATURE MEDICINE, 2022, 28 (09) :1933-+
[6]   Third Dose of the BNT162b2 Vaccine Results in Sustained High Levels of Neutralizing Antibodies Against SARS-CoV-2 at 6 Months Following Vaccination in Healthy Individuals [J].
Ntanasis-Stathopoulos, Ioannis ;
Karalis, Vangelis ;
Sklirou, Aimilia D. ;
Gavriatopoulou, Maria ;
Alexopoulos, Harry ;
Malandrakis, Panagiotis ;
Trougakos, Ioannis P. ;
Dimopoulos, Meletios A. ;
Terpos, Evangelos .
HEMASPHERE, 2022, 6 (07)
[7]   Age-specific mortality and immunity patterns of SARS-CoV-2 [J].
O'Driscoll, Megan ;
Ribeiro Dos Santos, Gabriel ;
Wang, Lin ;
Cummings, Derek A. T. ;
Azman, Andrew S. ;
Paireau, Juliette ;
Fontanet, Arnaud ;
Cauchemez, Simon ;
Salje, Henrik .
NATURE, 2020, 590 (7844) :140-145
[8]   Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients [J].
Ogata, Alana F. ;
Cheng, Chi-An ;
Desjardins, Michael ;
Senussi, Yasmeen ;
Sherman, Amy C. ;
Powell, Megan ;
Novack, Lewis ;
Von, Salena ;
Li, Xiaofang ;
Baden, Lindsey R. ;
Walt, David R. .
CLINICAL INFECTIOUS DISEASES, 2022, 74 (04) :715-718
[9]   Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination [J].
Roltgen, Katharina ;
Nielsen, Sandra C. A. ;
Silva, Oscar ;
Younes, Sheren F. ;
Zaslavsky, Maxim ;
Costales, Cristina ;
Yang, Fan ;
Wirz, Oliver F. ;
Solis, Daniel ;
Hoh, Ramona A. ;
Wang, Aihui ;
Arunachalam, Prabhu S. ;
Colburg, Deana ;
Zhao, Shuchun ;
Haraguchi, Emily ;
Lee, Alexandra S. ;
Shah, Mihir M. ;
Manohar, Monali ;
Chang, Iris ;
Gao, Fei ;
Mallajosyula, Vamsee ;
Li, Chunfeng ;
Liu, James ;
Shoura, Massa J. ;
Sindher, Sayantani B. ;
Parsons, Ella ;
Dashdorj, Naranjargal J. ;
Dashdorj, Naranbaatar D. ;
Monroe, Robert ;
Serrano, Geidy E. ;
Beach, Thomas G. ;
Chinthrajah, R. Sharon ;
Charville, Gregory W. ;
Wilbur, James L. ;
Wohlstadter, Jacob N. ;
Davis, Mark M. ;
Pulendran, Bali ;
Troxell, Megan L. ;
Sigal, George B. ;
Natkunam, Yasodha ;
Pinsky, Benjamin A. ;
Nadeau, Kari C. ;
Boyd, Scott D. .
CELL, 2022, 185 (06) :1025-+
[10]   Booster BNT162b2 optimizes SARS-CoV-2 humoral response in patients with myeloma: the negative effect of anti-BCMA therapy [J].
Terpos, Evangelos ;
Gavriatopoulou, Maria ;
Ntanasis-Stathopoulos, Ioannis ;
Briasoulis, Alexandros ;
Gumeni, Sentiljana ;
Malandrakis, Panagiotis ;
Papanagnou, Eleni-Dimitra ;
Migkou, Magdalini ;
Kanellias, Nikolaos ;
Kastritis, Efstathios ;
Trougakos, Ioannis P. ;
Dimopoulos, Meletios A. .
BLOOD, 2022, 139 (09) :1409-1412