Pulmonary Vaccine Delivery: A Realistic Approach?

被引：44

作者：

Tonnis, Wouter F. ^{[2
]}

Kersten, Gideon F. ^{[1
]}

Frijlink, Henderik W. ^{[2
]}

Hinrichs, Wouter L. J. ^{[2
]}

de Boer, Anne H. ^{[2
]}

Amorij, Jean-Pierre ^{[1
]}

机构：

[1] Natl Inst Hlth & Environm, Vaccinol Unit, NL-3721 MA Bilthoven, Netherlands

[2] Univ Groningen, Dept Pharmaceut Technol & Biopharm, Groningen, Netherlands

来源：

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY | 2012年 / 25卷 / 05期

关键词：

infection; intervention; pneumonia; adjuvant; deposition; inhaler; PNEUMOCOCCAL POLYSACCHARIDE VACCINE; MEASLES-VIRUS VACCINE; DRY POWDER INHALATION; IMMUNE-RESPONSES; INFLUENZA VACCINE; CROSS-PROTECTION; STREPTOCOCCUS-PNEUMONIAE; DIFFERENT STRAINS; MUCOSAL IMMUNITY; GUINEA-PIGS;

D O I：

10.1089/jamp.2011.0931

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pulmonary vaccine delivery has gained increasing attention during the last decade because this vaccination method combines potential advantages such as the fact that it omits the use of needles and may elicit immunity at the port of entry for many pathogens. In this review the current status of pulmonary vaccination, the potential advantages of pulmonary vaccine delivery, the hurdles to overcome in the future, and the overall perspectives of this vaccination strategy are described.

引用

页码：249 / 260

页数：12

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