Cardiac Troponins I and T: Molecular Markers for Early Diagnosis, Prognosis, and Accurate Triaging of Patients with Acute Myocardial Infarction

被引：57

作者：

Tiwari, Ram P. ^{[1
]}

Jain, Anubhav ^{[1
]}

Khan, Zakir ^{[2
]}

Kohli, Veena ^{[1
]}

Bharmal, R. N. ^{[3
]}

Kartikeyan, S. ^{[3
]}

Bisen, Prakash S. ^{[4
]}

机构：

[1] RFCL Ltd, Div Diagnost, Avantor Performance Mat, New Delhi, India

[2] Inst Pasteur, Dept Virol, Viral Neuroimmunol Unit, Paris, France

[3] Rajiv Gandhi Med Coll, Dept Microbiol, Kalwa, Thane, India

[4] Govt India, Minist Def, DRDE, DRDO, Gwalior 474002, India

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2012年 / 16卷 / 06期

关键词：

CORONARY-ARTERY-DISEASE; ST-SEGMENT ELEVATION; BRAIN NATRIURETIC PEPTIDE; ASSOCIATION TASK-FORCE; MULTIPLE BIOMARKERS; RISK STRATIFICATION; HIGH-SENSITIVITY; CARDIOVASCULAR EVENTS; CHEST-PAIN; PREDICTION;

D O I：

10.1007/s40291-012-0011-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Acute myocardial infarction (AMI) is the leading cause of death worldwide, with early diagnosis still being difficult. Promising new cardiac biomarkers such as troponins and creatine kinase (CK) isoforms are being studied and integrated into clinical practice for early diagnosis of AMI. The cardiac-specific troponins I and T (cTnI and cTnT) have good sensitivity and specificity as indicators of myocardial necrosis and are superior to CK and its MB isoenzyme (CK-MB) in this regard. Besides being potential biologic markers, cardiac troponins also provide significant prognostic information. The introduction of novel high-sensitivity troponin assays has enabled more sensitive and timely diagnosis or exclusion of acute coronary syndromes. This review summarizes the available information on the potential of troponins and other cardiac markers in early diagnosis and prognosis of AMI, and provides perspectives on future diagnostic approaches to AMI.

引用

页码：371 / 381

页数：11