The metabolomic signature of hematologic malignancies

被引：27

作者：

Allegra, Alessandro ^{[1
]}

Innao, Vanessa ^{[1
]}

Gerace, Demetrio ^{[1
]}

Bianco, Oriana ^{[1
]}

Musolino, Caterina ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Patol Umana Adulto & Eta Evolut Gaet, Via Consolare Valeria 1, I-98125 Messina, Italy

来源：

LEUKEMIA RESEARCH | 2016年 / 49卷

关键词：

Metabolomics; Hematological malignancies; Cancer; Warburg effect; Biomarkers; ACUTE MYELOID-LEUKEMIA; INDUCED CYTIDINE DEAMINASE; PERMEABILITY TRANSITION PORE; NON-HODGKIN-LYMPHOMA; BREAST-CANCER CELLS; B-CELL; GLUTAMINE-METABOLISM; FOLLICULAR LYMPHOMA; PYRUVATE-KINASE; AID EXPRESSION;

D O I：

10.1016/j.leukres.2016.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ongoing accumulation of knowledge raises hopes that understanding tumor metabolism will provide new ways for predicting, diagnosing, and even treating cancers. Some metabolic biomarkers are at present routinely utilized to diagnose cancer and metabolic alterations of tumors are being confirmed as therapeutic targets. The growing utilization of metabolomics in clinical research may rapidly turn it into one of the most potent instruments used to detect and fight tumor. In fact, while the current state and trends of high throughput metabolomics profiling focus on the purpose of discovering biomarkers and hunting for metabolic mechanism, a prospective direction, namely reprogramming metabolomics, highlights the way to use metabolomics approach for the aim of treatment of disease by way of reconstruction of disturbed metabolic pathways. In this review, we present an ample summary of the current clinical appliances of metabolomics in hematological malignancies. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：22 / 35

页数：14

共 198 条

[1] Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria [J].

Aichler, Michaela ;

Elsner, Mareike ;

Ludyga, Natalie ;

Feuchtinger, Annette ;

Zangen, Verena ;

Maier, Stefan K. ;

Balluff, Benjamin ;

Schoene, Cedrik ;

Hierber, Ludwig ;

Braselmann, Herbert ;

Meding, Stephan ;

Rauser, Sandra ;

Zischka, Hans ;

Aubele, Michaela ;

Schmitt, Manfred ;

Feith, Marcus ;

Hauck, Stefanie M. ;

Ueffing, Marius ;

Langer, Rupert ;

Kuster, Bernhard ;

Zitzelsberger, Horst ;

Hoefler, Heinz ;

Walch, Axel K. .

JOURNAL OF PATHOLOGY, 2013, 230 (04) :410-419

[2]

Akiyama Y, 2015, CANCER GENOM PROTEOM, V12, P133

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Analytical methods in untargeted metabolomics: state of the art in 2015 [J].

Alonso, Arnald ;

Marsal, Sara ;

Julia, Antonio .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2015, 3

[5] The Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilin [J].

Ambrosio, Maria R. ;

Piccaluga, Pier P. ;

Ponzoni, Maurilio ;

Rocca, Bruno J. ;

Malagnino, Valeria ;

Onorati, Monica ;

De Falco, Giulia ;

Calbi, Valeria ;

Ogwang, Martin ;

Naresh, Kikkeri N. ;

Pileri, Stefano A. ;

Doglioni, Claudio ;

Leoncini, Lorenzo ;

Lazzi, Stefano .

PLOS ONE, 2012, 7 (08)

[6] Pathobiology of ALK+ anaplastic large-cell lymphoma [J].

Amin, Hesham M. ;

Lai, Raymond .

BLOOD, 2007, 110 (07) :2259-2267

[7] Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice [J].

Andersen, S ;

Ericsson, M ;

Dai, HY ;

Peña-Diaz, J ;

Slupphaug, G ;

Nilsen, H ;

Aarset, H ;

Krokan, HE .

DNA REPAIR, 2005, 4 (12) :1432-1441

[8] Pharmaceutical research and metabolomics in the newborn [J].

Antonucci, Roberto ;

Pilloni, Maria Dolores ;

Atzori, Luigi ;

Fanos, Vassilios .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2012, 25 :22-26

[9] L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment [J].

Athanassakis, I ;

Mouratidou, M ;

Sakka, P ;

Evangeliou, A ;

Spilioti, M ;

Vassiliadis, S .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2001, 1 (9-10) :1813-1822

[10]

Baenke F., 2015, Mol. Oncol, P1

← 1 2 3 4 5 6 7 8 9 10 →