Degradation and miscibility of poly(DL-lactic acid)/poly(glycolic acid) composite films: Effect of poly(DL-lactic-co-glycolic acid)

被引：15
|
作者：
Ma, Zhigang [1 ]
Zhao, Na [1 ]
Xiong, Chengdong [2 ]
机构：
[1] Huangshi Inst Technol, Sch Chem & Mat Engn, Huangshi 435003, Peoples R China
[2] Chinese Acad Sci, Chengdu Organ Chem Co Ltd, Chengdu 610041, Peoples R China
来源：
BULLETIN OF MATERIALS SCIENCE | 2012年 / 35卷 / 04期
关键词：
Polymers; composite materials; thin films; microstructure; compatibility; IN-VITRO DEGRADATION; FIBERS;
D O I：
10.1007/s12034-012-0326-2
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The in vitro degradation behaviour of poly(glycolic acid) (PGA) and its composite films containing poly(DL-lactic acid) (PDLLA) and poly(DL-lactic-co-glycolic acid) (PDLGA) were investigated via mass loss, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). All the films were prepared by solution casting, using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the solvent. Since the degradation rate of PDLLA is lower than that of PGA, those of the PDLLA/PGA composite films decreased. As a compatibilizer, PDLGA improved the compatibility and hydrolytic stability of PDLLA/PGA composite films. Changes in the composite films indicate that this kind of PGA-based composite biomaterial may be applicable to device design for clinical application in the future.
引用
收藏
页码：575 / 578
页数：4
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