Synthesis of fluorine-containing 2-(1-aryl-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetic acids

被引：0

作者：

Fokin, A. S. ^{[1
]}

Burgart, Ya. V. ^{[1
]}

Saloutin, V. I. ^{[1
]}

Chupakhin, O. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Synth, Ural Div, Ekaterinburg 620219, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 41卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

Hydrolysis; Ethyl; Organic Chemistry; Toluene; Dehydration;

D O I：

10.1007/s11178-005-0349-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acid hydrolysis of ethyl 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetates gives 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2,2-dihydroxyacetic acids which undergo dehydration on heating in toluene to afford 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3yl)-2-oxoacetic acids. Reactions of the latter with excess morpholine result in replacement of two fluorine atoms in positions 5 and 7 by the amine residues.

引用

页码：1374 / 1376

页数：3

共 11 条

[1] Synthesis of fluorinated 2(3)-arylhydrazones of 1,2,3-tri(1,2,3,4-tetra)carbonyl compounds and their heterocyclization reactions
Burgart, YV
Fokin, AS
Kuzueva, OG
Chupakhin, ON
Saloutin, VI
[J]. JOURNAL OF FLUORINE CHEMISTRY, 1998, 92 (02) : 101 - 108
[2] Synthesis of 2-(1-alkyl(aryl)-4-oxo-5,6,7,8-tetrafluoro-1, 4-dihydroquinolin-3-yl)glyoxylic acid derivatives
Fokin, AS
Burgart, YV
Saloutin, VI
Chupakhin, ON
[J]. JOURNAL OF FLUORINE CHEMISTRY, 2001, 108 (02) : 187 - 194
[3] FOKIN AS, 2001, IZV ROSS AKAD NAUK S, P2307
[4] FOKIN AS, 2001, IZV AKAD NAUK K, P662
[5] GORDON AJ, 1972, CHEM COMPANION, P232
[6] MASHKOVSKII MD, 1986, LEKARSTVENNYE SREDST, V2, P294
[7] MITZUTANI M, 1989, B CHEM SOC JPN, V62, P2304
[8] Mokrushina G. A., 1991, Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva Imeni D. I. Mendeleeva, V36, P447
[9] MOKRUSHINA GA, 1999, RUSS J ORG CHEM+, V35, P1413
[10] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOCINNOLINE-3-CARBOXYLIC ACIDS
RADL, S
MOURAL, J
BENDOVA, R
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1990, 55 (05) : 1311 - 1320

← 1 2 →