How does BAFF activate B cells in patients with autoimmune diseases?

被引：4
作者：
Mariette, Xavier [1 ]
机构：
[1] Univ Paris 11, Hop Bicetre, AP HP, INSERM,Serv Rhumatol,U1012, F-94275 Le Kremlin Bicetre, France
来源：
ARTHRITIS RESEARCH & THERAPY | 2012年 / 14卷 / 01期
关键词：
PRIMARY SJOGRENS-SYNDROME; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LYMPHOCYTE STIMULATOR; SALIVARY-GLANDS; T-CELLS; EXPRESSION; DISORDERS; MONOCYTES;
D O I：
10.1186/ar3729
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In a study in a recent issue of Arthritis Research & Therapy, Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjogren's syndrome (SS) produce significantly higher amounts of B cell-activating factor (BAFF) and interleukin-6 (IL-6) in comparison with normal monocytes. This difference exists at baseline and is amplified after stimulation with interferon-gamma. Increased IL-6 secretion is partially suppressed by an anti-BAFF antibody, suggesting that signal transduction pathways mediated by BAFF are implicated in the regulation of IL-6 production by monocytes. The origin and pathways involved in this higher susceptibility to BAFF-driven IL-6 induction by monocytes of patients with SS are still unknown.
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页数：2
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[11]   Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren's syndrome [J].
Yoshimoto, Keiko ;
Tanaka, Maiko ;
Kojima, Masako ;
Setoyama, Yumiko ;
Kameda, Hideto ;
Suzuki, Katsuya ;
Tsuzaka, Kensei ;
Ogawa, Yoko ;
Tsubota, Kazuo ;
Abe, Tohru ;
Takeuchi, Tsutomu .
ARTHRITIS RESEARCH & THERAPY, 2011, 13 (05)
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