How does BAFF activate B cells in patients with autoimmune diseases?

被引：4

作者：

Mariette, Xavier ^{[1
]}

机构：

[1] Univ Paris 11, Hop Bicetre, AP HP, INSERM,Serv Rhumatol,U1012, F-94275 Le Kremlin Bicetre, France

来源：

ARTHRITIS RESEARCH & THERAPY | 2012年 / 14卷 / 01期

关键词：

PRIMARY SJOGRENS-SYNDROME; SYSTEMIC-LUPUS-ERYTHEMATOSUS; LYMPHOCYTE STIMULATOR; SALIVARY-GLANDS; T-CELLS; EXPRESSION; DISORDERS; MONOCYTES;

D O I：

10.1186/ar3729

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a study in a recent issue of Arthritis Research & Therapy, Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjogren's syndrome (SS) produce significantly higher amounts of B cell-activating factor (BAFF) and interleukin-6 (IL-6) in comparison with normal monocytes. This difference exists at baseline and is amplified after stimulation with interferon-gamma. Increased IL-6 secretion is partially suppressed by an anti-BAFF antibody, suggesting that signal transduction pathways mediated by BAFF are implicated in the regulation of IL-6 production by monocytes. The origin and pathways involved in this higher susceptibility to BAFF-driven IL-6 induction by monocytes of patients with SS are still unknown.

引用

页数：2

共 11 条

[1] Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjogren's syndrome [J].

Daridon, Capucine ;

Devauchelle, Valerie ;

Hutin, Pascal ;

Le Berre, Rozenn ;

Martins-Carvalho, Christine ;

Bendaoud, Boutahar ;

Dueyrnes, Maryvonne ;

Saraux, Alain ;

Youinou, Pierre ;

Pers, Jacques-Olivier .

ARTHRITIS AND RHEUMATISM, 2007, 56 (04) :1134-1144

[2] RETRACTED: Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus (Retracted Article) [J].

Doreau, Agnes ;

Belot, Alexandre ;

Bastid, Jeremy ;

Riche, Benjamin ;

Trescol-Biemont, Marie-Claude ;

Ranchin, Bruno ;

Fabien, Nicole ;

Cochat, Pierre ;

Pouteil-Noble, Claire ;

Trolliet, Pierre ;

Durieu, Isabelle ;

Tebib, Jacques ;

Kassai, Berhouz ;

Ansieau, Stephane ;

Puisieux, Alain ;

Eliaou, Jean-Francois ;

Bonnefoy-Berard, Nathalie .

NATURE IMMUNOLOGY, 2009, 10 (07) :778-U142

[3] B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjogren's syndrome [J].

Ittah, Marc ;

Miceli-Richard, Corinne ;

Gottenberg, Jacques-Eric ;

Lavie, Frederic ;

Lazure, Thierry ;

Ba, Nathalie ;

Sellam, Jeremie ;

Lepajolec, Christine ;

Mariette, Xavier .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (02)

[4] The B lymphocyte stimulator receptor-ligand system in hepatitis C virus-induced B cell clonal disorders [J].

Landau, D-A ;

Rosenzwajg, M. ;

Saadoun, D. ;

Klatzmann, D. ;

Cacoub, P. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (03) :337-344

[5] B-cell activating factor of the tumour necrosis factor family expression in blood monocytes and T cells from patients with primary Sjogren's syndrome [J].

Lavie, F. ;

Miceli-Richard, C. ;

Ittah, M. ;

Sellam, J. ;

Gottenberg, J. -E. ;

Mariette, X. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2008, 67 (02) :185-192

[6] Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren's syndrome [J].

Lavie, F ;

Miceli-Richard, C ;

Quillard, J ;

Roux, S ;

Leclerc, P ;

Mariette, X .

JOURNAL OF PATHOLOGY, 2004, 202 (04) :496-502

[7] Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations [J].

Mackay, F ;

Woodcock, SA ;

Lawton, P ;

Ambrose, C ;

Baetscher, M ;

Schneider, P ;

Tschopp, J ;

Browning, JL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1697-1710

[8] Pathogenesis of Sjogren's syndrome and therapeutic consequences [J].

Mariette, Xavier ;

Gottenberg, Jacques-Eric .

CURRENT OPINION IN RHEUMATOLOGY, 2010, 22 (05) :471-477

[9] Synthesis and release of B-lymphocyte stimulator from myeloid cells [J].

Nardelli, B ;

Belvedere, O ;

Roschke, V ;

Moore, PA ;

Olsen, HS ;

Migone, TS ;

Sosnovtseva, S ;

Carrell, JA ;

Feng, P ;

Giri, JG ;

Hilbert, DM .

BLOOD, 2001, 97 (01) :198-204

[10] Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjogren's syndrome and systemic lupus erythematosus [J].

Sellam, Jeremie ;

Miceli-Richard, Corinne ;

Gottenberg, Jacques-Eric ;

Ittah, Marc ;

Lavie, Frederic ;

Lacabaratz, Christine ;

Gestermann, Nicolas ;

Proust, Alexis ;

Lambotte, Olivier ;

Mariette, Xavier .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (06) :790-797

← 1 2 →