Enantioselective catalysis and analysis on a chip

被引：121
|
作者：
Belder, D [1 ]
Ludwig, M [1 ]
Wang, LW [1 ]
Reetz, MT [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期
关键词：
directed evolution; electrophoresis; enantiomer separation; high-throughput screening; microreactors;
D O I：
10.1002/anie.200504205
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chip off the old block: A prototype of a miniaturized catalysis laboratory is successfully applied for screening enantioselective biocatalysts created by directed evolution of enzymes. For this purpose an integrated microfluidic catalysis/analysis chip has been developed (see scheme SO: sample outlet, SI: alternative sample inlet, BI: buffer outlet). (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2463 / 2466
页数：4
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