Enantioselective catalysis and analysis on a chip

被引：121

作者：

Belder, D ^{[1
]}

Ludwig, M ^{[1
]}

Wang, LW ^{[1
]}

Reetz, MT ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期

关键词：

directed evolution; electrophoresis; enantiomer separation; high-throughput screening; microreactors;

D O I：

10.1002/anie.200504205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chip off the old block: A prototype of a miniaturized catalysis laboratory is successfully applied for screening enantioselective biocatalysts created by directed evolution of enzymes. For this purpose an integrated microfluidic catalysis/analysis chip has been developed (see scheme SO: sample outlet, SI: alternative sample inlet, BI: buffer outlet). (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2463 / 2466

页数：4

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