Impact of Ultrabithorax alternative splicing on Drosophila embryonic nervous system development

被引：6

作者：

Geyer, Aenne ^{[1
]}

Koltsaki, Ioanna ^{[1
]}

Hessinger, Christian ^{[1
]}

Renner, Simone ^{[1
]}

Rogulja-Ortmann, Ana ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Genet, D-55128 Mainz, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2015年 / 138卷

关键词：

Hox genes; Ultrabithorax; Neuroblast identity; CNS development; Alternative splicing; HOMEOBOX GENES; MELANOGASTER; EXPRESSION; PROTEINS; APOPTOSIS; FATE; NEUROECTODERM; ANTENNAPEDIA; DISSECTION; GENERATION;

D O I：

10.1016/j.mod.2015.08.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hox genes control divergent segment identities along the anteroposterior body axis of bilateral animals by regulating a large number of processes in a cell context-specific manner. How Hox proteins achieve this functional diversity is a long-standing question in developmental biology. In this study we investigate the role of alternative splicing in functional specificity of the Drosophila Hox gene Ultrabithorax (Ubx). We focus specifically on the embryonic central nervous system (CNS) and provide a description of temporal expression patterns of three major Ubx isoforms during development of this tissue. These analyses imply distinct functions for individual isoforms in different stages of neural development. We also examine the set of Ubx isoforms expressed in two isoform-specific Ubx mutant strains and analyze for the first time the effects of splicing defects on regional neural stem cell (neuroblast) identity. Our findings support the notion of specific isoforms having different effects in providing individual neuroblasts with positional identity along the anteroposterior body axis, as well as being involved in regulation of progeny cell fate. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：177 / 189

页数：13

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