Robotic-assisted Radical Cystectomy With Extracorporeal Urinary Diversion for Urothelial Carcinoma of the Bladder: Analysis of Complications and Oncologic Outcomes in 175 Patients With a Median Follow-up of 3 Years

被引:35
作者
Xylinas, Evanguelos
Green, David A.
Otto, Brandon
Jamzadeh, Asha
Kluth, Luis
Lee, Richard K.
Robinson, Brian D.
Shariat, Shahrokh F.
Scherr, Douglas S.
机构
[1] Weill Cornell Med Coll, Dept Urol, New York, NY USA
[2] Weill Cornell Med Coll, Div Med Oncol, New York, NY USA
[3] Weill Cornell Med Coll, Dept Pathol, New York, NY USA
关键词
TRANSITIONAL-CELL CARCINOMA; LYMPHOVASCULAR INVASION; ADJUVANT THERAPY; LYMPH-NODES; CANCER; SURVIVAL; VALIDATION; RECURRENCE; CONSORTIUM;
D O I
10.1016/j.urology.2013.07.048
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To report oncologic outcomes and complications after robotic-assisted radical cystectomy (RARC). MATERIALS AND METHODS From March 2004 to August 2011, 175 consecutive patients underwent RARC with extracorporeal urinary diversion at our institution by a single surgeon. The study design was prospective. Perioperative parameters and postoperative complications were prospectively collected using the modified Clavien system. Recurrence-free survival and cancer-specific survival curves were generated using the Kaplan-Meier method. RESULTS A total of 145 men and 30 women with a median age of 73 years and a median body mass index of 27 kg/m(2) underwent RARC. Four patients (2.3%) required conversion to open surgery because of difficulty to progress. One hundred nine patients (62%) underwent a transcutaneous ileal conduit, 40 patients (23%) an orthotopic neobladder, and 26 (15%) a continent cutaneous conduit. The median operating time was 360 minutes (interquartile range [IQR]: 300-420). The median estimated blood loss was 400 mL (IQR: 250-612), with a transfusion rate of 17.0%. The median postoperative length of stay was 7.0 days (IQR: 5.2-10). Early (<30 days) and late surgery-related complications (30-90 days) occurred in 74 (42%) and 59 (34%) patients, respectively. The perioperative mortality rate was 2.8%. The positive soft tissue surgical margins rate was 5%. The median number of lymph nodes removed was 19 (IQR: 12-28). The median follow-up was 37 months (IQR: 21.5-53.5). Actuarial recurrence-free survival and cancer-specific survival at 2, 3, and 5 years after RARC were 67%, 63%, 63% and 73%, 68%, 66%, respectively. CONCLUSION RARC achieved mid-term oncologic efficacy. Moreover, the complication rates were comparable with open radical cystectomy series. (C) 2013 Elsevier Inc.
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收藏
页码:1323 / 1329
页数:7
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