Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

被引：197
作者：
Benson, Heather A. E. [1 ]
Grice, Jeffrey E. [2 ]
Mohammed, Yousuf [2 ]
Namjoshi, Sarika [2 ]
Roberts, Michael S. [2 ,3 ]
机构：
[1] Curtin Univ Technol, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, Perth, WA, Australia
[2] Univ Queensland, Translat Res Inst, Diamantina Inst, Perth, WA 4102, Australia
[3] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA, Australia
来源：
CURRENT DRUG DELIVERY | 2019年 / 16卷 / 05期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
History; skin delivery; nanotechnology; physical enhancement; microneedles; minimally invasive; transdermal technologies; targeted delivery; stratum corneum; follicular transport; wearable devices; DISSOLVING MICRONEEDLE PATCH; SOLID LIPID NANOPARTICLES; NANOLIPID CARRIER APPLICATION; IN-VITRO; SKIN ELECTROPORATION; INFLUENZA VACCINE; DNA VACCINATION; PENETRATION ENHANCER; CUTANEOUS DELIVERY; TARGETED DELIVERY;
D O I：
10.2174/1567201816666190201143457
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.
引用
收藏
页码：444 / 460
页数：17
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