D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses

被引:0
作者
Otmakhova, NA
Lisman, JE
机构
[1] BRANDEIS UNIV,CTR COMPLEX SYST,DEPT BIOL,WALTHAM,MA 02254
[2] BRANDEIS UNIV,VOLEN CTR COMPLEX SYST,DEPT BIOL,WALTHAM,MA 02254
关键词
CA1; cAMP; catecholamine depletion; D1/D5 dopamine receptors; early LTP; field EPSP; forskolin; hippocampus;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of the mesolimbic dopaminergic system in the reinforcement of learning suggests that dopamine should be able to nodulate activity-dependent synaptic plasticity, We have examined the effect of D1/D5 agonists on early long-term potentiation (LTP) (40 min) in the CA1 region of hippocampal slices. D1/D5 agonists (+)bromo-APB, 6-chloro-PB, and dihydrexidine Increased the magnitude of LTP in a synapse-specific manner (by similar to 10, 15, and 20%, respectively). This D1/D5 effect was mimicked by a low dose (10 mu m) of the adenylyl cyclase activator forskolin. The D1/D5 antagonist (+)SCH 23390 reduced early LTP. In catecholamine-depleted slices, LTP was by similar to 20-25% and could nai be decreased further by D1/D5 antagonist. Under these conditions, D1/D5 agonist 6-chloro-PB and forskolin produced a larger enhancement of LTP (20-25%), restoring it to the control level, At the same dose, dideoxyforskolin did not affect early LTP. The D1/D5 agonist effect was completely blocked by the D1/D5 antagonist (+)SCH 23390. These results indicate that dopamine produces a synapse-specific enhancement of early LTP through D1/D5 receptors and cAMP.
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页码:7478 / 7486
页数:9
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