Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis

被引：14

作者：

Li, Hui ^{[1
,2
]}

Tang, Xiaojun ^{[1
,2
]}

Liu, Qin ^{[1
,2
]}

Wang, Yang ^{[1
,2
]}

机构：

[1] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China

[2] Consortium China, RPC Programme, Effect Hlth Care Res Programme, Chongqing, Peoples R China

来源：

ACTA DIABETOLOGICA | 2013年 / 50卷 / 05期

关键词：

CDKN2A/B; rs10811661; Type; 2; diabetes; Polymorphism; Meta-analysis; GENOME-WIDE ASSOCIATION; RISK LOCI; VARIANTS; IGF2BP2; CDKAL1; GENES; TCF7L2; HHEX; SLC30A8; FTO;

D O I：

10.1007/s00592-012-0400-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the association between type 2 diabetes and rs10811661 polymorphism, upstream of CDKN2A/B, a literature-based search was conducted to collect data. The pooled OR (odds ratio) and 95 % confidence intervals (CI) were used to assess the strength of association between rs10811661 polymorphism and type 2 diabetes. OR with 95 % CI were performed for allele contrasts, additive genetic model, dominant genetic model and recessive genetic model, respectively. The effect model was used if there was heterogeneity between studies. Funnel plots were used to predict publication bias. 17 studies with 29,990 cases and 40,977 controls were enrolled in this meta-analysis. Significant association was found in all of the four genetic models: allele contrast (OR = 1.21, 95 % CI 1.18-1.24), additive genetic model (OR = 1.51, 95 % CI 1.40-1.63), dominant genetic model (OR = 1.37, 95 % CI 1.28-1.47) and recessive genetic model (OR = 1.25, 95 % CI 1.21-1.29). The meta-analysis indicated that rs10811661 polymorphism was significantly associated with the risk of type 2 diabetes.

引用

页码：657 / 662

页数：6

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