Nitric oxide and apoptosis in mesangial cells

被引：23

作者：

Brüne, B ^{[1
]}

机构：

[1] Univ Kaiserslautern, Fac Biol, Dept Cell Biol, D-67663 Kaiserslautern, Germany

来源：

KIDNEY INTERNATIONAL | 2002年 / 61卷 / 03期

关键词：

nitric oxide; superoxide; apoptosis; necrosis; survival; p53; caspases; Bcl-2; family; programmed cell death;

D O I：

10.1046/j.1523-1755.2002.00221.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Radicals such as nitric oxide (NO) or superoxide (O-2(-)) encompass the ability to initiate morphological and biochemical alterations that are reminiscent of apoptosis. In mesangial cells, death as a result of NO formation is efficiently antagonized by the simultaneous presence of superoxide (O-2(-)) and vice versa. This article reviews the consequences of a diffusion controlled NO/O-2(-) interaction with the outcome of redirecting the apoptotic initiating activity of either NO or O-2(-) toward protection. The crosstalk between cell destructive and protective pathways, and their activation or inhibition under the modulatory influence of NO and/or O-2(-) are summarized.

引用

页码：786 / 789

页数：4

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