Metabolic regulation on the immune environment of glioma through gut microbiota

被引：36

作者：

Lyu, Yingying ^{[1
]}

Yang, Hui ^{[1
,2
,3
]}

Chen, Liang ^{[1
,3
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai, Peoples R China

[2] Fudan Univ, Inst Translat Brain Res, Shanghai Med Coll, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Shanghai Clin Med Ctr Neurosurg, MOE Frontiers Ctr Brain Sci,Shanghai Key Lab Brain, Shanghai, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 86卷

关键词：

Gut microbiota; Glioma; Immune; Metabolites; Gut-brain axis; CHAIN FATTY-ACIDS; T-CELLS; NERVOUS SYSTEMS; DENDRITIC CELLS; BILE-ACIDS; BUTYRATE; EXPRESSION; MATURATION; DIFFERENTIATION; GLIOBLASTOMA;

D O I：

10.1016/j.semcancer.2021.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gut-brain axis has paved our way in understanding varieties of disease. The gut microbiota especially the bacterial population plays critical roles in immune system development and function. Glioma comprises 80 percent of malignant brain cancer and glioblastoma (GBM) is the most malignant kind. GBM has a reputation for its suppressive immune environment and poor patient prognosis. Moreover, altered metabolites from gut microbiota affect both systemic immune and central nervous system (CNS) immunity. Here we will focus on the crosstalk between gut microbiota and GBM, and further explore how this communication contributes to glioma initiation and development. Finally, we highlight the latest insights on the metabolic regulation of immunity through gut microbiota, which provides a promising therapeutic strategy for GBM.

引用

页码：990 / 997

页数：8

共 110 条

[1] Gut microbiome and CAR-T therapy [J].

Abid, Muhammad Bilal ;

Shah, Nirav N. ;

Maatman, Theresa C. ;

Hari, Parameswaran N. .

EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2019, 8 (01)

[2] SIRT1 regulates circadian clock gene expression through PER2 deacetylation [J].

Asher, Gad ;

Gatfield, David ;

Stratmann, Markus ;

Reinke, Hans ;

Dibner, Charna ;

Kreppel, Florian ;

Mostoslavsky, Raul ;

Alt, Frederick W. ;

Schibler, Ueli .

CELL, 2008, 134 (02) :317-328

[3]

Bäckhed F, 2015, CELL HOST MICROBE, V17, P690, DOI [10.1016/j.chom.2015.04.004, 10.1016/j.chom.2015.05.012]

[4] Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis [J].

Baj, Andreina ;

Moro, Elisabetta ;

Bistoletti, Michela ;

Orlandi, Viviana ;

Crema, Francesca ;

Giaroni, Cristina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (06)

[5]

BAUER H, 1963, AM J PATHOL, V42, P471

[6] Butyrate increases IL-23 production by stimulated dendritic cells [J].

Berndt, Bradford E. ;

Zhang, Min ;

Owyang, Stephanie Y. ;

Cole, Tyler S. ;

Wang, Teresa W. ;

Luther, Jay ;

Veniaminova, Natalia A. ;

Merchant, Juanita L. ;

Chen, Chun-Chia ;

Huffnagle, Gary B. ;

Kao, John Y. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (12) :G1384-G1392

[7] The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT [J].

Bettegowda, Chetan ;

Huang, Xin ;

Lin, Jimmy ;

Cheong, Ian ;

Kohli, Manu ;

Szabo, Stephen A. ;

Zhang, Xiaosong ;

Diaz, Luis A., Jr. ;

Velculescu, Victor E. ;

Parmigiani, Giovanni ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Zhou, Shibin .

NATURE BIOTECHNOLOGY, 2006, 24 (12) :1573-1580

[8] Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets [J].

Bi, Junfeng ;

Chowdhry, Sudhir ;

Wu, Sihan ;

Zhang, Wenjing ;

Masui, Kenta ;

Mischel, Paul S. .

NATURE REVIEWS CANCER, 2020, 20 (01) :57-70

[9] The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity [J].

Bliss, Edward S. ;

Whiteside, Eliza .

FRONTIERS IN PHYSIOLOGY, 2018, 9

[10] The Pharmacology and Function of Receptors for Short-Chain Fatty Acids [J].

Bolognini, Daniele ;

Tobin, Andrew B. ;

Milligan, Graeme ;

Moss, Catherine E. .

MOLECULAR PHARMACOLOGY, 2016, 89 (03) :388-398

← 1 2 3 4 5 6 7 8 9 10 →