The key must fit: macrophages transport prion infection to the central nervous system and may determine the sites of infection within it

被引：6
作者：
Dealler, S
机构：
[1] Burnley General Hospital, Burnley
来源：
MEDICAL HYPOTHESES | 1997年 / 49卷 / 03期
关键词：
D O I：
10.1016/S0306-9877(97)90205-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It is suggested that the agent for transmissible spongiform encephalopathies is trasferred from an original peripheral site of infection into the brain by recruited and selected circulating macrophages/monocytes. It is because of this selection that strains of disease appear to be different when infecting separate species, but retain characteristics when infecting a single species.
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页码：213 / 220
页数：8
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