The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration

被引：37

作者：

Chang, In Ho ^{[1
]}

Ahn, Seung Hyun ^{[2
]}

Han, June Hyun ^{[2
]}

Kim, Tae-Hyoung ^{[1
]}

Kim, Young Sun ^{[1
]}

Myung, Soon Chul ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Med, Dept Urol, Seoul 156756, South Korea

[2] Hanil Gen Hosp, KEPCO Med Fdn, Seoul, South Korea

来源：

JOURNAL OF UROLOGY | 2009年 / 181卷 / 02期

关键词：

prostatic neoplasms; obesity; tumor markers; biological; hemodilution; body mass index; PROSTATE-SPECIFIC ANTIGEN; BODY-MASS INDEX; FATTY LIVER-DISEASE; PSA CONCENTRATION; CANCER; VELOCITY; RISK;

D O I：

10.1016/j.juro.2008.10.030

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We investigated the association between body mass index and the concentration of tumor markers including carcinoembryonic antigen, alpha-fetoprotein, the carbohydrate antigen 19-9 and prostate specific antigen, as well as the association between body mass index changes and tumor marker concentration changes in a population of healthy men. Materials and Methods: We evaluated data on 8,776 men screened for tumor markers (carcinoembryonic antigen, a-fetoprotein, carbohydrate antigen 19-9 and prostate specific antigen) at least 3 times annually during an annual examination from 2001 to 2007. We assessed the tumor marker test findings for a trend in the age, alanine aminotransferase and creatinine adjusted tumor marker concentration by body mass index. We used multivariate regression analysis to determine whether a change in body mass index was associated with a tumor marker concentration change over time using calculated tumor markers, body mass index, creatinine and alanine aminotransferase concentration change per year. Results: After adjusting for age, creatinine and alanine aminotransferase a higher body mass index was associated with lower prostate specific antigen (p for trend <0.001), carcinoembryonic antigen (p for trend <0.001) and carbohydrate antigen 19-9 (p for trend <0.001). On multivariate regression analysis each I kg/m(2) of body mass index gain per year was associated with a -0.011 ng/ml change in prostate specific antigen concentration, a -0.030 ng/ml change in carcinoembryonic antigen concentration and a -0.192 IU/ml change in carbohydrate antigen 19-9 concentration per year. Conclusions: In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual.

引用

页码：567 / 572

页数：6

共 20 条

[11]

Farnsworth WE, 1999, PROSTATE, V41, P263, DOI 10.1002/(SICI)1097-0045(19991201)41:4<263::AID-PROS7>3.0.CO

[12]

2-0

[13] Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat [J].