Serotonin in the gut: Blessing or a curse

被引:100
作者
Banskota, Suhrid [1 ,2 ]
Ghia, Jean-Eric [3 ]
Khan, Waliul, I [1 ,2 ]
机构
[1] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Hamilton, ON, Canada
[2] McMaster Univ, Dept Pathol & Mol Med, Room 3N7, Hamilton, ON L8N 3Z5, Canada
[3] Univ Manitoba, Dept Immunol & Internal Med, Winnipeg, MB, Canada
关键词
Serotonin; 5-HT; Inflammation; Gut; Immune response; STIMULATED INSULIN-SECRETION; MOUSE PANCREATIC-ISLETS; IMMUNE-RESPONSES; DUODENAL MUCOSA; GASTROINTESTINAL MOTILITY; ENTEROCHROMAFFIN CELLS; REUPTAKE TRANSPORTER; EXPERIMENTAL COLITIS; ULCERATIVE-COLITIS; GLUCAGON-SECRETION;
D O I
10.1016/j.biochi.2018.06.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a neurotransmitter of the central nervous system, is seen to be predominantly secreted in the gut. About 95% of 5-HT is estimated to be found in gut mainly within the enterochromaffin cells whereas about 5% is found in the brain. 5-HT is an important enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. In recent times, studies uncovering various new functions of gut-derived 5-HT indicate that many more are yet to be discovered in coming days. Recent studies revealed that 5-HT plays a pivotal role in immune cell activation and generation/perpetuation of inflammation in the gut. In addition to its various roles in the gut, there are now emerging evidences that suggest an important role of gut-derived 5-HT in other biological processes beyond the gut, such as bone remodeling and metabolic homeostasis. This review focuses to briefly summarize the accumulated and newly updated role of 5-HT in the maintenance of normal gut physiology and in the pathogenesis of inflammation in the gut. The collected information about this multifaceted signaling molecule may aid in distinguishing its good and bad effects which may lead to the development of novel strategies to overcome the unwanted effect, such as in inflammatory bowel disease. (C) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码:56 / 64
页数:9
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