The Complement System in Liver Diseases

被引：0

作者：

Qin, Xuebin ^{[1
]}

Gao, Bin ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02139 USA

[2] NIAAA, Sect Liver Biol, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2006年 / 3卷 / 05期

关键词：

immunity; complement; liver disease;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases.

引用

页码：333 / 340

页数：8

共 83 条

[61] Anti-C1q antibodies in hepatitis C virus infection [J].

Saadoun, D. ;

Sadallah, S. ;

Trendelenburg, M. ;

Limal, N. ;

Sene, D. ;

Piette, J. C. ;

Schifferli, J. A. ;

Cacoub, P. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 145 (02) :308-312

[62] Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells [J].

Schieferdecker, HL ;

Pestel, S ;

Rothermel, E ;

Püschel, GP ;

Götze, O ;

Jungermann, K .

FEBS LETTERS, 1998, 434 (03) :245-250

[63] Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver [J].

Schieferdecker, HL ;

Rothermel, E ;

Timmermann, A ;

Gotze, O ;

Jungermann, K .

FEBS LETTERS, 1997, 406 (03) :305-309

[64] Functions of anaphylatoxin C5a in rat liver:: direct and indirect actions on nonparenchymal and parenchymal cells [J].

Schieferdecker, HL ;

Schlaf, G ;

Jungermann, K ;

Götze, O .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2001, 1 (03) :469-481

[65]

Schlaf G, 2004, HISTOL HISTOPATHOL, V19, P1165, DOI 10.14670/HH-19.1165

[66] C4d in acute rejection after liver transplantation - A valuable tool in differential diagnosis to hepatitis C recurrence [J].

Schmeding, M ;

Dankof, A ;

Krenn, V ;

Krukemeyer, MG ;

Koch, M ;

Spinelli, A ;

Langrehr, JM ;

Neumann, UP ;

Neuhaus, P .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (03) :523-530

[67] The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: Four components of the lectin pathway activation complex encoded by two genes [J].

Schwaeble, W ;

Dahl, MR ;

Thiel, S ;

Stover, C ;

Jensenius, JC .

IMMUNOBIOLOGY, 2002, 205 (4-5) :455-466

[68] Complement activation after ischemia-reperfusion in human liver allografts: Incidence and pathophysiological relevance [J].

Scoazec, JY ;

BorghiScoazec, G ;

Durand, F ;

Bernuau, J ;

Pham, BN ;

Belghiti, J ;

Feldmann, G ;

Degott, C .

GASTROENTEROLOGY, 1997, 112 (03) :908-918

[69] Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus [J].

Seelen, MA ;

Trouw, LA ;

Daha, MR .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2003, 12 (06) :619-624

[70] Complement in different stages of HIV infection and pathogenesis [J].

Speth, C ;

Stoiber, H ;

Dierich, MP .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2003, 130 (04) :247-257

← 1 2 3 4 5 6 7 8 9 →