The Complement System in Liver Diseases

被引：0

作者：

Qin, Xuebin ^{[1
]}

Gao, Bin ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02139 USA

[2] NIAAA, Sect Liver Biol, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2006年 / 3卷 / 05期

关键词：

immunity; complement; liver disease;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases.

引用

页码：333 / 340

页数：8

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