Efficient Synthesis of Conjugated 1,3,4-Thiadiazole Hybrids through Palladium-Catalyzed Cross-Coupling of 2,5-Bis(4-bromophenyl)-1,3,4-thiadiazole with Boronic Acids

被引：10
作者：
Wroblowska, Monika [1 ]
Kudelko, Agnieszka [1 ]
Lapkowski, Mieczyslaw [2 ,3 ]
机构：
[1] Silesian Tech Univ, Dept Chem Organ Technol & Petrochem, PL-44100 Gliwice, Poland
[2] Silesian Tech Univ, Dept Phys Chem & Technol Polymers, PL-44100 Gliwice, Poland
[3] Polish Acad Sci, Ctr Polymer & Carbon Mat, PL-41819 Zabrze, Poland
来源：
SYNLETT | 2015年 / 26卷 / 15期
关键词：
heterocycles; cross-coupling; phase-transfer catalysis; palladium; catalysis; LIGHT-EMITTING-DIODES; ANTIMICROBIAL ACTIVITY; SIDE-CHAIN; DEVICE; ELECTROLUMINESCENCE; 1,3,4-OXADIAZOLES; ELECTROCHEMISTRY; DERIVATIVES; POLYMER;
D O I：
10.1055/s-0034-1378826
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New derivatives of 2,5-bis(4-heteroarylphenyl)-1,3,4-thiadiazole were synthesized under Suzuki cross-coupling reactions from 2,5-bis(4-bromophenyl)-1,3,4-thiadiazole and commercially available boronic acids. Reactions were conducted in a two-phase solvent system in the presence of catalytic amounts of tetrakis(triphenylphosphine)palladium(0), cesium carbonate as a base, and tetrabutylammonium bromide playing a role of a phase-transfer catalyst.
引用
收藏
页码：2127 / 2130
页数：4
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