Reductive N-methylation of quinolines with paraformaldehyde and H2 for sustainable synthesis of N-methyl tetrahydroquinolines

被引：19
|
作者：
Wang, Hongli [1 ]
Huang, Yongji [1 ]
Jiang, Qi [1 ]
Dai, Xingchao [1 ,2 ]
Shi, Feng [1 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
[2] Univ Chinese Acad Sci, 19A Yuquanlu, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 27期
关键词：
CARBON-DIOXIDE; SECONDARY-AMINES; CATALYST; HYDROGENATION; ALKALOIDS;
D O I：
10.1039/c8cc10309g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new and straightforward method was developed for the synthesis of N-methyl-1,2,3,4-tetrahydroquinolines by one-pot reductive N-methylation of quinolines with paraformaldehyde and H-2 over Pd/C catalyst. A series of functional MTHQs, including (+/-)-galipinine and (+/-)-angustrureine were successfully synthesized in good to excellent yields by applying this simple catalyst system.
引用
收藏
页码：3915 / 3918
页数：4
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