Towards molecular movies with X-ray photon correlation spectroscopy

被引：32

作者：

Perakis, Fivos ^{[1
]}

Gutt, Christian ^{[2
]}

机构：

[1] Stockholm Univ, AlbaNova Univ Ctr, Dept Phys, S-10691 Stockholm, Sweden

[2] Univ Siegen, Dept Phys, D-57072 Siegen, Germany

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2020年 / 22卷 / 35期

基金：

瑞典研究理事会;

关键词：

SPECKLE-VISIBILITY SPECTROSCOPY; RADIATION-DAMAGE; SUPERCOOLED WATER; DYNAMICAL TRANSITION; PROTEIN SOLUTIONS; PHASE-BEHAVIOR; DATA REDUCTION; LIQUID; CELL; TEMPERATURE;

D O I：

10.1039/d0cp03551c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this perspective article we highlight research opportunities and challenges in probing structural dynamics of molecular systems using X-ray Photon Correlation Spectroscopy (XPCS). The development of new X-ray sources, such as 4th generation storage rings and X-ray free-electron lasers (XFELs), provides promising new insights into molecular motion. Employing XPCS at these sources allows to capture a very broad range of timescales and lengthscales, spanning from femtoseconds to minutes and atomic scales to the mesoscale. Here, we discuss the scientific questions that can be addressed with these novel tools for two prominent examples: the dynamics of proteins in biomolecular condensates and the dynamics of supercooled water. Finally, we provide practical tips for designing and estimating feasibility of XPCS experiments as well as on detecting and mitigating radiation damage.

引用

页码：19443 / 19453

页数：11

共 104 条

[31] Optimizing the signal-to-noise ratio for X-ray photon correlation spectroscopy [J].

Falus, P ;

Lurio, LB ;

Mochrie, SGJ .

JOURNAL OF SYNCHROTRON RADIATION, 2006, 13 :253-259

[32] Water: A Tale of Two Liquids [J].

Gallo, Paola ;

Arnann-Winkel, Katrin ;

Angell, Charles Austen ;

Anisimov, Mikhail Alexeevich ;

Caupin, Frederic ;

Chakravarty, Charusita ;

Lascaris, Erik ;

Loerting, Thomas ;

Panagiotopoulos, Athanassios Zois ;

Russo, John ;

Sellberg, Jonas Alexander ;

Stanley, Harry Eugene ;

Tanaka, Hajime ;

Vega, Carlos ;

Xu, Limei ;

Pettersson, Lars Gunnar Moody .

CHEMICAL REVIEWS, 2016, 116 (13) :7463-7500

[33] A closer look at arrested spinodal decomposition in protein solutions [J].

Gibaud, Thomas ;

Schurtenberger, Peter .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2009, 21 (32)

[34] Ferroelectric domain wall dynamics characterized with X-ray photon correlation spectroscopy [J].

Gorfman, Semen ;

Bokov, Alexei A. ;

Davtyan, Arman ;

Reiser, Mario ;

Xie, Yujuan ;

Ye, Zuo-Guang ;

Zozulya, Alexey V. ;

Sprung, Michael ;

Pietsch, Ullrich ;

Gutt, Christian .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (29) :E6680-E6689

[35]

Gr��bel G., 2008, Soft Matter Characterization, P953, DOI [10.1007/978-1-4020-4465-6_18, DOI 10.1007/978-1-4020-4465-6_18]

[36] Dynamics of proteins in solution [J].

Grimaldo, Marco ;

Roosen-Runge, Felix ;

Zhang, Fajun ;

Schreiber, Frank ;

Seydel, Tilo .

QUARTERLY REVIEWS OF BIOPHYSICS, 2019, 52

[37] Correlation spectroscopy with coherent X-rays [J].

Grübel, G ;

Zontone, F .

JOURNAL OF ALLOYS AND COMPOUNDS, 2004, 362 (1-2) :3-11

[38] Decoupling of viscosity and relaxation processes in supercooled water: a molecular dynamics study with the TIP4P/2005f model [J].

Guillaud, Emmanuel ;

Merabia, Samy ;

de Ligny, Dominique ;

Joly, Laurent .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 19 (03) :2124-2130

[39] Measuring temporal speckle correlations at ultrafast x-ray sources [J].

Gutt, C. ;

Stadler, L. -M. ;

Duri, A. ;

Autenrieth, T. ;

Leupold, O. ;

Chushkin, Y. ;

Gruebel, G. .

OPTICS EXPRESS, 2009, 17 (01) :55-61

[40] Model Reconstruction from Small-Angle X-Ray Scattering Data Using Deep Learning Methods [J].

He, Hao ;

Liu, Can ;

Liu, Haiguang .

ISCIENCE, 2020, 23 (03)

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